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    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
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    Target
    HHV-6 gp60/110 (2)
    Application
    IF (2)IHC (1)IP (2)WB (2)
    Host
    Mouse (2)
    Type
    Mouse antibody (2)
    Species Reactivity
    HHV-6 (2)
    Expression Host
    CHO (2)
    Derivation
    Mouse (2)
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    S100A1

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
    Protein class

    Cancer-related genes, Plasma proteins, Transporters

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enriched (Proximal tubular cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Group enriched (Hep G2, SK-MEL-30)

    Interaction

    Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain (PubMed:21296671). Also forms heterodimers with S100P (PubMed:15171681). Interacts with AGER (By similarity). Interacts with CAPZA1 (By similarity). Interacts with FKBP4 (PubMed:20188096). Interacts with RYR1 and RYR2 (PubMed:18650434). Interacts with CACYBP in a calcium-dependent manner (PubMed:12042313). Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (PubMed:22399290). Interacts with ATP2A2 and PLN in a Ca(2+)-dependent manner (PubMed:12804600). Interacts with mitochondrial F1-ATPase subunits ATP5F1A and ATP5F1B; these interactions increase F1-ATPase activity (By similarity).

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