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SCN1A
Loading...Anti-SCN1A Products
- Rat Anti-SCN1A Recombinant Antibody (VS-0522-LC161) (VS-0522-LC161)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: IB, IP, ELISA, IF, IHC
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- Human Anti-SCN1A Recombinant Antibody (VS-0522-LC162) (VS-0522-LC162)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: IB, IP, ELISA, IF, IHC
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- Rabbit Anti-SCN1A Recombinant Antibody (VS-0522-LC163) (VS-0522-LC163)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: IB, IP, ELISA, IF, IHC
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- Mouse Anti-SCN1A Recombinant Antibody (VS-0522-LC171) (VS-0522-LC171)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: ICC, WB
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- Rat Anti-SCN1A Recombinant Antibody (VS-0522-LC172) (VS-0522-LC172)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: ICC, WB
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- Human Anti-SCN1A Recombinant Antibody (VS-0522-LC173) (VS-0522-LC173)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: ICC, WB
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- Rabbit Anti-SCN1A Recombinant Antibody (VS-0522-LC174) (VS-0522-LC174)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: ICC, WB
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- Mouse Anti-SCN1A Recombinant Antibody (VS-0522-LC175) (VS-0522-LC175)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: ICC, IHC, WB
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- Rat Anti-SCN1A Recombinant Antibody (VS-0522-LC176) (VS-0522-LC176)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: ICC, IHC, WB
Compare
- Human Anti-SCN1A Recombinant Antibody (VS-0522-LC177) (VS-0522-LC177)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: ICC, IHC, WB
Compare
- Rabbit Anti-SCN1A Recombinant Antibody (VS-0522-LC178) (VS-0522-LC178)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: ICC, IHC, WB
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For Research Use Only. Not For Clinical Use.
SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1) is a Protein Coding gene. Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Diseases associated with SCN1A include Dravet Syndrome and Generalized Epilepsy With Febrile Seizures Plus, Type 2.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters, Voltage-gated ion channels
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (ASC TERT1, Hep G2)
Interaction
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and/or beta-4 (SCN4B). Beta-1 (SCN1B) and beta-3 (SCN3B) are non-covalently associated with alpha, while beta-2 (SCN2B) and beta-4 (SCN4B) are covalently linked by disulfide bonds. Interacts with FGF13 (PubMed:21566136). Interacts with SCN1B (PubMed:17928445, PubMed:15525788). Interacts with the conotoxin GVIIJ (PubMed:24497506). Interacts with the spider beta/delta-theraphotoxin-Pre1a (PubMed:28428547).
Molecular function
Ion channel, Sodium channel, Voltage-gated channel
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