Intracellular
Group enriched (Cardiomyocytes, Smooth muscle cells)
Group enriched (eosinophil, neutrophil)
Cell line enhanced (K-562, THP-1)
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPTIN2 and SEPTIN5. In platelets, associated with a complex containing STX4. Interacts with PRKN; this interaction leads to SEPTIN5 ubiquitination and degradation (By similarity). Interacts with DYRK1A (By similarity). Interacts with STX1A; in the cerebellar cortex (By similarity).
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For Research Use Only. Not For Clinical Use.