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SLAMF7
Anti-SLAMF7 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
SLAMF7, also called CS1, is another member of the SLAM family. It is expressed on the surface of multiple immune cell types, including NK cells, plasma cells, and some subsets of T cells. Structurally, like other SLAM family members, it has an extracellular domain with immunoglobulin - like regions, a transmembrane segment, and a cytoplasmic tail containing ITSMs.
Protein class
CD markers, FDA approved drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells, monocytes, NK-cells, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enriched (U-266/70)
Interaction
Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro); low affinity binding, the physiological relevance of the interaction is questioned. Interacts with SH2D1B; in NK cells (PubMed:16339536). Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK and FYN (By similarity).
Molecular function
Receptor
More Types Infomation