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TCF7L1
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Leydig cells, Adipocytes)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (HBEC3-KT, NTERA-2, RH-30, T-47d)
Interaction
Binds the armadillo repeat of CTNNB1 and forms a stable complex.
Molecular function
Activator, DNA-binding, Repressor
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.