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TDP2
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)
Immune cell specificity
Group enriched (neutrophil, basophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4. (Microbial infection) Interacts with Hantaan hantavirus nucleoprotein. (Microbial infection) Interacts with Seoul hantavirus nucleoprotein.
Molecular function
Hydrolase, Nuclease
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: FC, ICC, IF, WB
- Recombinant Mouse Anti-TDP2 Antibody (VS-0923-FY242) (VS-0923-FY242)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
- Recombinant Mouse Anti-TDP2 Antibody (VS-0923-FY168) (VS-0923-FY168)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.