TFCP2

Formats

Anti-TFCP2 Recombinant Antibody Products

Recombinant Mouse Anti-Human TFCP2 Antibody (MOB-0720MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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Recombinant Mouse Anti-TFCP2 Antibody (VS-0923-FY142) (VS-0923-FY142)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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Recombinant Mouse Anti-TFCP2 Antibody (VS-0923-FY143) (VS-0923-FY143)
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.

This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]

Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons, Microglial cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.

Molecular function

DNA-binding

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