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THEMIS2
Anti-THEMIS2 Recombinant Antibody Products
- PE-A*29:02/Human THEMIS2 (FIKDGSSTY) MHC Tetramer (MHC-LC4314)
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- Class: Class I
- Antigen: THEMIS2
- Antigen Species: Human
- Peptide: FIKDGSSTY
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.
Thymocytes are hematopoietic progenitor cells present in the thymus. Thymopoiesis is the process in the thymus by which thymocytes differentiate into mature T lymphocytes. The primary function of thymocytes is the generation of T lymphocytes (T cells). The thymus provides an inductive environment, which allows for the development and selection of physiologically useful T cells. The processes of beta-selection, positive selection, and negative selection shape the population of thymocytes into a peripheral pool of T cells that are able to respond to foreign pathogens and are immunologically tolerant towards self antigens.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (monocytes, Kupffer cells, Macrophages, dendritic cells, Hofbauer cells, Langerhans cells, Plasma cells)
Immune cell specificity
Group enriched (neutrophil, non-classical monocyte, intermediate monocyte, classical monocyte, eosinophil, myeloid DC, plasmacytoid DC)
Cell line specificity
Cell line enhanced (Karpas-707, U-266/70, U-937)
Interaction
Interacts with VAV1. Interacts with LAT. Interacts constitutively with GRB2, LYN and PLCG2; these interactions increase the activation of PLCG2 and its downstream pathways following B cell receptor stimulation.
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