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TRADD
Loading...Anti-TRADD Products
- Anti-Canine TRADD Antibody (MOB-0229MC)
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- Species Reactivity: Canine, Mouse, Rat and Human
- Application: WB, IF, IP, ELISA
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- Recombinant Mouse Anti-Human TRADD Antibody (MOB-1822MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- AbPlus™ Anti-TRADD Magnetic Beads (VS-0724-YC467) (VS-0724-YC467)
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- Target: TRADD
- Target Species: Human
- Application: IP, Protein Purification
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- Mouse Anti-TRADD Recombinant Antibody (clone 3A1E8) (VS7-0425-WR1039)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
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- Anti-TRADD Immunohistochemistry Kit (VS-0325-XY2343)
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- Species Reactivity: Human, Mouse
- Target: TRADD
- Application: IHC
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- Anti-Human TRADD Immunohistochemistry Kit (VS-0525-XY7487)
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- Species Reactivity: Human
- Target: TRADD
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (monocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Stimulation of TNF-alpha receptor TNFRSF1A leads to the formation of two distinct signaling complexes (PubMed:7758105, PubMed:8612133, PubMed:14585990, PubMed:21307340). Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival (PubMed:7758105, PubMed:8612133, PubMed:14585990, PubMed:21307340). Subsequently, TRADD, RIPK1 and TRAF2 dissociate from TNFRSF1A and form cytoplasmic complex II with FADD and caspase CASP8 promoting cell apoptosis (PubMed:21307340). Within complex I, interacts with TNFRSF1A/TNFR1, TRAF2 and kinase RIPK1 (PubMed:7758105, PubMed:10892748, PubMed:8612133). Within complex I, interacts with TRPC4AP; the interaction promotes NF-kappa B activation (PubMed:14585990). UXT1 associates with complex I; the interaction prevents the formation of complex II (PubMed:21307340). Within complex I Interacts with scaffold protein DAB2IP (PubMed:15310755). Interacts with autophagy receptor SQSTM1 (PubMed:10356400). Interacts with E3 ligase TRIP12 (By similarity). Interacts with kinase HIPK2 (PubMed:11032752). Interacts with keratin KRT14 (PubMed:11684708). Interacts with keratin KRT18 (PubMed:11684708). Interacts with keratins KRT16 and KRT17 (By similarity). Interacts with FADD (By similarity). Interacts with TOMM70 (PubMed:20628368).
More Types Infomation
Related Diseases
Colorectal Cancer
Maturity Onset Diabetes of the Young
Related Signaling Pathways
TNF Signaling Pathway