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UNC5B
Anti-UNC5B Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
Protein class
Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Horizontal cells, Oligodendrocytes, Muller glia cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HaCaT, HHSteC, hTCEpi, SH-SY5Y)
Interaction
Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part (PubMed:12359238). Interacts (via death domain) with DAPK1 (via death domain) (PubMed:15729359, PubMed:18582460). Interacts (via extracellular domain) with FLRT3 (via extracellular domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with FLRT2 and FLRT3 (via extracellular domain), but has higher affinity for FLRT3 (PubMed:25374360). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (PubMed:26235030).
Molecular function
Developmental protein, Receptor
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