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VCL
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BJ hTERT+, hTERT-RPE1)
Interaction
Exhibits self-association properties. Part of a complex composed of THSD1, PTK2/FAK1, TLN1 and VCL (PubMed:29069646). Interacts with APBB1IP and NRAP (By similarity). Interacts with TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin (By similarity). Interacts with SYNM. Interacts with SORBS1 (By similarity). Interacts with CTNNA1 (PubMed:26691986). Binds to ACTN4; this interaction triggers conformational changes (PubMed:15988023).
Molecular function
Actin-binding
More Types Infomation
- PE-A*02:01/Human VCL (RILGAVAKV) MHC Tetramer (MHC-LC2456)
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- Class: Class I
- Antigen: VCL
- Antigen Species: Human
- Peptide: RILGAVAKV
- Conjugate: PE
- PE-A*02:01/Human VCL (GLDVLTAKV) MHC Tetramer (MHC-LC2455)
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- Class: Class I
- Antigen: VCL
- Antigen Species: Human
- Peptide: GLDVLTAKV
- Conjugate: PE
- Rabbit Anti-VCL Recombinant Antibody (clone JM42-43) (MRO-1586-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IP
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
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- Species Reactivity: Human
- Application: ICC/IF, IHC-P, IP, WB
- Mouse Anti-VCL Recombinant Antibody (clone 8G3) (MOB-3635z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, IF, FC, ELISA
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, ICC, FC
- Recombinant Rabbit Anti-VCL Antibody (clone R09-1F3) (VS3-FY1540)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P
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For Research Use Only. Not For Clinical Use.