abfD

This fascinating bifunctional enzyme is involved in the anaerobic metabolism of various compounds, particularly in bacterial pathways for the degradation of 4-hydroxybutyrate. It catalyzes two distinct reactions: the dehydration of 4-hydroxybutyryl-CoA and the isomerization of vinylacetyl-CoA. This dual activity is critical for channeling intermediates through a specific metabolic pathway, often linked to energy generation.