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    Recombinant Anti-human ABL Intrabody [(D-Arg)9] (CAT#: IAB-B048(A))

    Recombinant anti-ABL intrabody linked to (D-Arg)9 works within cells and specifically reacts with human ABL, expressed in CHO cells. Inhibition of the BCR/ABL protein tyrosine kinase activity by the intrabody blocked BCR/ABL signal transduction pathway,reversed the effect of BCR/ABL on cell growth and apoptosis.

    Specific Inquiry
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    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
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    Conjugation :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & nuclear bodies.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/27280/259_B8_2_selected.jpg
    Figure 2 IF staining of human cell line U-2 OS
    Figure 2 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28409/497_A9_2_selected.jpg
    Normal Tissue
    Figure 3 IHC staining of human heart muscle
    Figure 3 IHC staining of human heart muscle
    (Immunohistochemical staining of human heart muscle shows strong cytoplasmic positivity in myocytes.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/27251/ihc_selected.jpg
    Figure 4 IHC staining of human prostate
    Figure 4 IHC staining of human prostate
    (Immunohistochemical staining of human prostate shows cytoplasmic and membranous positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/27280/ihc_selected.jpg
    Figure 5 IHC staining of human adrenal gland
    Figure 5 IHC staining of human adrenal gland
    (Immunohistochemical staining of human adrenal gland shows strong nuclear positivity in cortical cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28409/ihc_selected.jpg
    Figure 6 IHC staining of human duodenum
    Figure 6 IHC staining of human duodenum
    (Immunohistochemical staining of human duodenum shows moderate cytoplasmic positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/2686/ihc_selected.jpg
    Figure 7 Cerebral cortex
    Figure 7 Cerebral cortex
    (Neuropil
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28409/61378_B_8_5.jpg
    Figure 8 Adrenal gland
    Figure 8 Adrenal gland
    (Glandular cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28409/61378_B_5_5.jpg
    Figure 9 Colon
    Figure 9 Colon
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Peripheral nerve/ganglion
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28409/61494_A_9_3.jpg
    Figure 10 Liver
    Figure 10 Liver
    (Hepatocytes
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28409/61494_A_9_4.jpg
    Figure 11 Kidney
    Figure 11 Kidney
    (Cells in glomeruli
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear
    Cells in tubules
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/28409/61494_A_9_5.jpg
    RNA Expression
    Figure 12 RNA cell line category: Low cell line specificity
    Figure 12 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000097007-ABL1

    Specifications

    • Immunogen
    • human ABL proto-oncogene 1, non-receptor tyrosine kinase
    • Host Species
    • mouse
    • Type
    • scFv-(D-Arg)9
    • Cell Penetrating Peptide
    • (D-Arg)9
      It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
    • Species Reactivity
    • human
    • Applications
    • Can be useful in applications such as: Flow Cytometry; Immunofluorescence; Functional studies

    Product Property

    • Purity
    • Purity>95% by SDS-PAGE
    • Storage
    • Store at -20°C. Open under aseptic conditions.

    Target

    • Alternative Names
    • Abelson murine leukemia viral oncogene homolog 2; Abelson related gene protein; Abelson tyrosine-protein kinase 2;
      Abelson-related gene protein; ABL2; ABL2_HUMAN; ABLL; ARG; Tyrosine kinase ARG; Tyrosine protein kinase ABL2; Tyrosine-protein kinase A

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    Intrabody Products
    CAT Product Name Application Type
    IAB-B048(G) Recombinant Anti-human ABL Intrabody [+36 GFP] CO-IP, FuncS scFv-(+36GFP)
    IAB-B048(T) Recombinant Anti-human ABL Intrabody [Tat] ELISA, IF, Neut, FuncS scFv-Tat

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