Recombinant Human Anti-Betula Bet v1 Antibody (BV16) (CAT#: PABZ-014)
Recombinant Human Antibody (BV16) is capable of binding to Betula Bet v1, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-Betula Bet v1 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-Betula Bet v1 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. BV16 inhibits the binding of human serum IgE to Bet v 1 by ∼40%. Moreover, the BV16 mAb shows cross-reactivity with the homologous major allergens from alder and hornbeam.
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Figure 1 kinetic parameters for the binding of mAb BV16 are shown below each model.
No binding to Mal d 1 could be detected, whereas very similar kinetic parameters characterize BV16 antibody binding to Bet v 1 and Mut-2782 were found.
Holm, J., Ferreras, M., Ipsen, H., Würtzen, P. A., Gajhede, M., Larsen, J. N., ... & Spangfort, M. D. (2011). Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1. Journal of Biological Chemistry, 286(20), 17569-17578.
Specifications
- Immunogen
- BetulaBet v I allergen
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Betula Bet v1
- Species Reactivity
- Betula
- Clone
- BV16
- Applications
- Can be useful in applications such as: Enzyme-linked Immunosorbent Assay
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- Bet v I allergen
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
ScFv Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-014 | Recombinant Human Anti-Betula Bet v1 Antibody Fab Fragment (BV16) | ELISA | |
| HPAB-1515WJ-F(E) | Human Anti-Bet v I Recombinant Antibody; Fab Fragment (clone G17E7A1) | ELISA, WB, IP | Human Fab |
| HPAB-1516WJ-F(E) | Human Anti-Bet v I Recombinant Antibody; Fab Fragment (clone G27E9B1) | ELISA, WB, IP | Human Fab |
| HPAB-1517WJ-F(E) | Human Anti-Bet v I Recombinant Antibody; Fab Fragment (clone G5F2A4) | ELISA, WB, IP | Human Fab |
| HPAB-1518WJ-F(E) | Human Anti-Bet v I Recombinant Antibody; Fab Fragment (clone G11A9F3) | ELISA, WB, IP | Human Fab |
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For Research Use Only. Not For Clinical Use.
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