Anti-Human CD22 Recombinant Antibody (VM1000)
CAT#: TAB-002LC
Recombinant monoclonal antibody to CD22. VM1000 is a humanized antibody that can be potentially used in the treatment of non-Hodkin's lymphoma, acute lymphocytic leukemia and chronic lymphocytic leukemia.
Published Data
Tested Data
Gene Expression
FC
Figure 1 shows data for the surface binding and internalization analysis on CD22 expressing human lymphoma cells, such as Daudi, RAMOS and RAJI B cell lines by fluorescent activated cell sorting (FACS) of selected clone from VM1000.
FuncS
Figure 2 show induction of CD22 tyrosine phosphorylation of CD22 present on the surface of the human lymphoma cell line Daudi upon exposure to selected antibodies from VM1000, VM1001, VM1002, VM1003, VM1004, VM1005, VM1006, VM1007, VM1008, VM1009, VM1010, VM1011, VM1012, VM1013, VM1014, and VM1015
FuncS
Figure 3 show induction of CD22 tyrosine phosphorylation of CD22 present on the surface of the human lymphoma cell line Daudi upon exposure to selected antibodies from VM1000, VM1001, VM1002, VM1003, VM1004, VM1005, VM1006, VM1007, VM1008, VM1009, VM1010, VM1011, VM1012, VM1013, VM1014, and VM1015
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SDS-PAGE
Figure 1 Anti-Human CD22 Recombinant Antibody (TAB-002LC) in SDS-PAGE
SDS-PAGE analysis of TAB-002LC in non-reduced and β-mercaptoethanol-reduced conditions.
SEC-HPLC
Figure 2 Anti-Human CD22 Recombinant Antibody (TAB-002LC) in HPLC
The purity of TAB-002LC was greater than 94% as determined by SEC-HPLC.
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Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg
Normal Tissue
Figure 2 Spleen
Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- VM1000
- Applications
- FC, ELISA, SPR, FuncS
- Related Disease
- Non-Hodkin's lymphoma, Acute lymphocytic leukemia, Chronic lymphocytic leukemia
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry and Functional Assay. Please see the Published Data for further information.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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