Anti-Human CD22 Recombinant Antibody (VM1000)

Name: Anti-Human CD22 Recombinant Antibody (VM1000)
SKU: TAB-002LC
Rating: 5 (1 reviews)

CAT#: TAB-002LC

Recombinant monoclonal antibody to CD22. VM1000 is a humanized antibody that can be potentially used in the treatment of non-Hodkin's lymphoma, acute lymphocytic leukemia and chronic lymphocytic leukemia.

Published Data Tested Data Gene Expression

Figure 1 shows data for the surface binding and internalization analysis on CD22 expressing human lymphoma cells, such as Daudi, RAMOS and RAJI B cell lines by fluorescent activated cell sorting (FACS) of selected clone from VM1000.

FuncS

Figure 2 show induction of CD22 tyrosine phosphorylation of CD22 present on the surface of the human lymphoma cell line Daudi upon exposure to selected antibodies from VM1000, VM1001, VM1002, VM1003, VM1004, VM1005, VM1006, VM1007, VM1008, VM1009, VM1010, VM1011, VM1012, VM1013, VM1014, and VM1015

FuncS

Figure 3 show induction of CD22 tyrosine phosphorylation of CD22 present on the surface of the human lymphoma cell line Daudi upon exposure to selected antibodies from VM1000, VM1001, VM1002, VM1003, VM1004, VM1005, VM1006, VM1007, VM1008, VM1009, VM1010, VM1011, VM1012, VM1013, VM1014, and VM1015

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SDS-PAGE

Figure 1 Anti-Human CD22 Recombinant Antibody (TAB-002LC) in SDS-PAGE

SDS-PAGE analysis of TAB-002LC in non-reduced and β-mercaptoethanol-reduced conditions.

SEC-HPLC

Figure 2 Anti-Human CD22 Recombinant Antibody (TAB-002LC) in HPLC

The purity of TAB-002LC was greater than 94% as determined by SEC-HPLC.

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Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg

Normal Tissue Figure 2 Spleen

Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22

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Specifications

Host Species
Human

Derivation
Humanized

Type
Humanized antibody

Specificity
Human

Clone
VM1000

Applications
FC, ELISA, SPR, FuncS

Related Disease
Non-Hodkin's lymphoma, Acute lymphocytic leukemia, Chronic lymphocytic leukemia

Applications

Application Notes
This antibody has been tested for use in Flow Cytometry and Functional Assay. Please see the Published Data for further information.

Target

Alternative Names
CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

Gene ID
933

UniProt ID
P20273

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-002LC.pdf

MSDS

MSDS - TAB-002LC.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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