Anti-HER2/neu Antibody-Cytokine Fusion Protein, IgG-GM-CSF

Name: Anti-HER2/neu Antibody-Cytokine Fusion Protein, IgG-GM-CSF
SKU: ACFP-SH063
Rating: 5 (1 reviews)

CAT#: ACFP-SH063

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HER2/neu IgG to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HER2/neu as well as the biological activity of GM-CSF. In addition, the anti-HER2/neu IgG3-(GM-CSF) protein was capable of activating J774.2 murine macrophage cells enhancing their direct cytotoxic activity and also enhancing antibody-dependent macrophage-mediated tumor cell lysis. The anti-HER2/neu IgG3-(GM-CSF) fusion protein will be useful in the treatment of human HER2/neu-expressing tumors. This immunocytokine was designed for treating HER-2/neu over-expressing cancer.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg

Normal Tissue Figure 3 High expression in esophagus

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg

Normal Tissue Figure 4 IHC staining of human rectum

Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg

Normal Tissue Figure 5 IHC staining of human urinary bladder

Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg

Normal Tissue Figure 6 Kidney

Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg

Normal Tissue Figure 7 Breast

Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

❮

❯

Specifications

Target
HER2/neu

Molecule Class
L Kappa; IgG1-GM-CSF

Species Reactivity
Human

Expression Host
CHO

Clone
trastuzumab

Related Disease
HER-2/neu over-expressing cancer

Cytokine 1
GM-CSF

Cytokines 1 Description
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called molgramostim.

Cytokine 1 Species
Human

Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog

Gene ID
2064

UniProt ID
P04626

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for ACFP-SH063. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Related Diseases

Bladder Cancer

Non-small Cell Lung Cancer

Related Signaling Pathways

ErbB Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - ACFP-SH063.pdf

MSDS

MSDS - ACFP-SH063.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "Clone Trastuzumab"

CAT
Product Name

See other products for "ERBB2"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
IAB-B008(A)	Recombinant Anti-human ERBB2 Intrabody [(D-Arg)₉]	IF, FC, FuncS	scFv-(D-Arg)₉
IAB-B008(G)	Recombinant Anti-human ERBB2 Intrabody [+36 GFP]	WB, ICC, FuncS	scFv-(+36GFP)
IAB-B008(T)	Recombinant Anti-human ERBB2 Intrabody [Tat]	ICC, Neut, FuncS	scFv-Tat

CAT	Product Name	Application	Type
TAB-761	Anti-ERBB2 Recombinant Antibody (Margetuximab)	IF, IP, Neut, FuncS, ELISA, FC, WB	IgG1 - kappa
TAB-049CT	Anti-Human HER2/neu Recombinant Antibody (ChA21)	IHC, Inhib, WB, Activ, FC	Chimeric antibody (mouse/human)
TAB-049CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21)	WB	Chimeric antibody (mouse/human)
TAB-049CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21)	WB	Chimeric antibody (mouse/human)

CAT	Product Name	Application
AGTO-G022E	Anti-ERBB2 immunotoxin 4D5 (scFv)-PE	Cytotoxicity assay, Function study
AGTO-G022D	Anti-ERBB2 immunotoxin 4D5 (scFv)-DT	Cytotoxicity assay, Function study
AGTO-G022G	Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel	Cytotoxicity assay, Function study
AGTO-G022R	Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA	Cytotoxicity assay, Function study
AGTO-G022S	Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap	Cytotoxicity assay, Function study

CAT	Product Name	Application	Type
PABL-466	Human Anti-ERBB2 Recombinant Antibody (clone mAb37)	WB	Human IgG
HPAB-1111LY	Mouse Anti-ERBB2 Recombinant Antibody (HPAB-1111LY)	IHC, FuncS, FC	Mouse IgG
HPAB-1112LY	Human Anti-ERBB2 Recombinant Antibody (HPAB-1112LY)	ELISA	Chimeric (Mouse/Human) IgG
MRO-1926-CN	Rabbit Anti-ErbB2 Polyclonal Antibody (MRO-1926-CN)	WB, IF, IHC	Rabbit IgG
MRO-1927-CN	Rabbit Anti-ErbB2 Polyclonal Antibody (MRO-1927-CN)	WB, IF, IHC, FC	Rabbit IgG

CAT	Product Name	Application
TAB-034CT	Anti-Human HER2/neu Recombinant Antibody (TAB-034CT)	WB
TAB-036CT	Anti-Human HER2/neu Recombinant Antibody (6B2)	ELISA, WB
TAB-037CT	Anti-Human HER2/neu Recombinant Antibody (7C2/7F3)	ELISA, WB
TAB-034CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (TAB-034CT-F(E))	WB
TAB-036CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (6B2)	ELISA, WB

CAT	Product Name	Application	Type
TAB-056CT	Human Anti-ERBB2 Recombinant Antibody (TAB-056CT)	WB	Human IgG
TAB-040CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (C6.5)	FC, IP, Block	Human antibody
TAB-042CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (CRX01)	WB	Human antibody
PABX-081-F (E)	Recombinant Human Anti-HER2 Antibody Fab Fragment (Gr3 )	WB, ELISA, FuncS	Fab
PABX-082-F (E)	Recombinant Human Anti-HER2 Antibody Fab Fragment (Gr6)	WB, ELISA, FuncS	Fab

CAT	Product Name	Application	Type
TAB-033CT-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-033CT-S(P))	ELISA, WB	Human scFv
TAB-038CT-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-038CT-S(P))	WB	Humanized scFv
TAB-039CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (h1E11)	WB	Humanized antibody
TAB-041CT-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-041CT-S(P))	ELISA, WB	Humanized scFv
TAB-050CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (HuA21)	ELISA, WB	Humanized antibody

CAT	Product Name	Application	Type
TAB-032CT	Anti-Human HER2/neu Single Domain Antibody, Research Grade Biosimilar	WB	Single domain antibody
TAB-046CT	Anti-Human HER2/neu Single Domain Antibody (TAB-046CT), Research Grade Biosimilar	ELISA, Inhibition, FC	Single domain antibody
TAB-047CT	Anti-Human HER2/neu Single Domain Antibody (TAB-047CT), Research Grade Biosimilar	WB	Single domain antibody
HPAB-0201-FY	Recombinant llama Anti-ERBB2 Antibody (HPAB-0201-FY)	E	llama VHH
HPAB-1026WJ	Recombinant Camelid Anti-ERBB2 Single Domain Antibody	ELISA	Camelid VHH

CAT	Product Name	Application	Type
Gly-024LC	Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation)	ELISA	Mouse antibody

CAT	Product Name	Application	Type
Gly-117LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Humanized antibody
Gly-145LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-146LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-147LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-148LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-177LC	Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
BRD-0195MZ	Chicken Anti-ERBB2 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-737CQ	Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4)	Block, IP, IF, FC	Mouse IgG2a

CAT	Product Name	Application	Type
MOR-1178	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB)	IHC-P, IHC-Fr	Rabbit IgG
MOR-4586	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS)	WB	Rabbit IgG
MOR-4587	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS)	WB	Rabbit IgG

CAT	Product Name	Application
MHC-LC2523	PE-B*07:02/Human ERBB2 (MPNQAQMRI) MHC Tetramer	FCM
MHC-LC2524	PE-B*35:01/Human ERBB2 (MPNQAQMRI) MHC Tetramer	FCM
MHC-LC2525	PE-B*51:01/Human ERBB2 (MPNQAQMRI) MHC Tetramer	FCM
MHC-LC2526	PE-B*53:01/Human ERBB2 (MPNQAQMRI) MHC Tetramer	FCM
MHC-LC2527	PE-B*54:01/Human ERBB2 (MPNQAQMRI) MHC Tetramer	FCM

CAT	Product Name	Application	Type
HPAB-0091-FY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone MIL12); Fab Fragment	ELISA	Humanized Fab
HPAB-0733LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone AH06); Fab Fragment	ELISA	Human Fab
HPAB-0734LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone A058); Fab Fragment	ELISA	Human Fab
HPAB-0735LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone AH16); Fab Fragment	ELISA	Human Fab
HPAB-0736LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone A091); Fab Fragment	ELISA	Human Fab

CAT	Product Name	Application	Type
HPAB-1111LY-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1111LY-S(P))	ELISA	Mouse scFv
HPAB-1112LY-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1112LY-S(P))	ELISA	Human scFv
HPAB-0193-WJ-S(P)	Mouse Anti-ERBB2 Recombinant Antibody (clone 6H8); scFv Fragment	ELISA	Mouse scFv
HPAB-M0073-YC-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0073-YC-S(P))	ELISA, FC	Human scFv
HPAB-M0074-YC-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0074-YC-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-468CQ	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-468CQ)	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody
AFC-TAB-053	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-053)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
AFC-TAB-761	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-761)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-005	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-005)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY91	AbPlus™ Anti-ERBB2 Magnetic Beads (3.F2)	IP, Protein Purification
VS-0724-YC1516	AbPlus™ Anti-Erbb2 Magnetic Beads (VS-0724-YC1516)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY24	Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera	FC, BI	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY108	CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC430	Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY2335	Anti-ERBB2 Immunohistochemistry Kit	IHC
VS-0525-XY2336	Anti-Mouse ERBB2 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC3	Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab	ELISA	Symmetric scFv-Fab
VS-0525-YC6	Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero Fab	ELISA	Asymmetric hetero Fab
VS-0525-YC7	Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero HC-LC	ELISA, Inhib	Asymmetric hetero HC, common LC

Specific Inquiry

Add to compare

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 4 Anti-CD22 Antibody (TAB-198) in Flow Cytometry

Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) (CAT# TAB-198)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 2 Anti-Human CD30 Recombinant Antibody (TAB-144) in ELISA

Anti-Human CD30 Recombinant Antibody (Iratumumab) (CAT# TAB-144)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 2 Anti-alpha 4 beta 7 Antibody (TAB-H75) in Dot Blot

Anti-Human ITGA4+ITGB7 Recombinant Antibody (TAB-H75) (CAT# TAB-H75)
Application: FC, IP, ELISA, Neut, FuncS, IF, WB

Figure 3 Anti-Human EGFR Antibody (TAB-003) in DB

Anti-Human EGFR Recombinant Antibody (Cetuximab) (CAT# TAB-003)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-Human CD19 Recombinant Antibody (TAB-108CL) in ELISA

Anti-Human CD19 Recombinant Antibody (TAB-108CL) (CAT# TAB-108CL)
Application: FC, ADCC, FuncS

Figure 1 Anti-histone Antibody-Cytokine Fusion Protein, IgG-IL12 (ACFP-SH113) in ELISA

Anti-histone Antibody-Cytokine Fusion Protein, IgG (NHS76)-IL12 (CAT# ACFP-SH113)
Application:

Figure 1 Human IgG4 Isotype Control Antibody (MOB-0408ZL) in SDS-PAGE

Human IgG4 Isotype Control Antibody (CAT# MOB-0408ZL)
Application: ELISA, IB, FC, IHC, FuncS

Figure 3 Anti-HIV-1 gp120 Antibody (PABL-163) in Dot Blot

Human Anti-HIV-1 gp120 Recombinant Antibody (clone 3bnc117) (CAT# PABL-163)
Application: Neut, ELISA, FuncS

Figure 2 Anti-Human EGFR Antibody (PABW-088) in DB

Mouse Anti-EGFR Recombinant Antibody (clone 7A7) (CAT# PABW-088)
Application: ELISA, WB

Figure 1 Mouse Anti-α4β7 Recombinant Antibody (PABL-746) in ELISA

Mouse Anti-α4β7 Recombinant Antibody (PABL-746) (CAT# PABL-746)
Application: FC

Figure 2 Anti-LPA Recombinant Antibody (TAB-0340CL) in HPLC

Anti-LPA Recombinant Antibody (LT3015 [B7(LT3000, Lpathomab)]) (CAT# TAB-0340CL)
Application: ELISA, SPR, Inhib, FuncS

Figure 2 Anti-CD3 Recombinant Antibody (TAB-0416CL-F(E)) in HPLC

Mouse Anti-CD3 Recombinant Antibody Fab Fragment (TAB-0416CL-F(E)) (CAT# TAB-0416CL-F(E))
Application: IB, ELISA, FC, FuncS

Figure 5 Human Anti-TREM2 Recombinant Antibody (TAB-168CQ) in ELISA

Human Anti-TREM2 Recombinant Antibody (TAB-168CQ) (CAT# TAB-168CQ)
Application: ELISA, FC, WB, FuncS

Figure 5 Mouse Anti-HIV-1 p24 Recombinant Antibody (MRO-928CQ) in ELISA

Mouse Anti-HIV-1 p24 Recombinant Antibody (MRO-928CQ) (CAT# MRO-928CQ)
Application: ELISA

Figure 2 Mouse Anti-ERBB2 Recombinant Antibody (NEUT-737CQ) in HPLC

Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) (CAT# NEUT-737CQ)
Application: Block, IP, IF, FC

Figure 2 Anti-Human MUC1 Recombinant Antibody (TAB-026ML) in HPLC

Anti-Human MUC1 Recombinant Antibody (TAB-026ML) (CAT# TAB-026ML)
Application: ELISA, IHC, FC, IP, IF, FuncS

Figure 3 Rat Anti-IL18 Recombinant Antibody (HPAB-0067-YC-F(E)) in ELISA

Rat Anti-IL18 Recombinant Antibody (clone 2C10); Fab Fragment (CAT# HPAB-0067-YC-F(E))
Application: Neut

Figure 3 Anti-TPO Recombinant Antibody (FAMAB-0014JF) in DB

Human Anti-TPO Recombinant Antibody (clone B8) (CAT# FAMAB-0014JF)
Application: WB, ELISA, IHC

Figure 17 Human Anti-IAV HA Recombinant Antibody (PABJ-0204) in DB

Human Anti-IAV HA Recombinant Antibody (PABJ-0204) (CAT# PABJ-0204)
Application: ELISA, Inhib, FuncS

Figure 2 Anti-FAP Antibody in ELISA.

Mouse Anti-FAP Recombinant Antibody (clone F19) (CAT# HPAB-A1368-YJ)
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.