Anti-HER2/neu Antibody-Cytokine Fusion Protein, IgG (L19)-IFNα (CAT#: ACFP-SH048)

• Target
• HER2/neu

• Molecule Class
• IgG3-IFNα

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• L19

• Related Disease
• HER-2/neu over-expressing cancer

• Cytokine 1
• IFNα

• Cytokines 1 Description
• Interferon alpha-1/13 is a protein that in humans is encoded by the IFNA1 gene. In humans, there are 13 different IFN-alpha genes, designated as IFN-α1,-α2,-α4,-α5,-α6,-α7,-α8,-α10,-α13,-α14,-α16,-α17 and-α21, and one each of the IFN beta (IFNB), IFN-Epsilon, IFN-Kappa and IFN-Omega genes. The human IFNA gene family shares 70-80% amino acid sequence homology, and about 35% identity with IFNB. The high degree of amino-acid sequence similarity within the IFNA genes suggests a common ancestor gene. It seems likely that the IFNA gene cluster has been generated by gene conversion or recent duplication events. There are 12 functional human IFNA gene products. All of these IFN-α proteins exhibit high homology in their primary, secondary, and tertiary structures. IFNA and IFNB are produced by a wide range of cells such as macrophages, fibroblasts and endothelial cells, but plasmacytoid dendritic cells (pDCs) are considered the main producers of IFNA in response to RNA or DNA viruses or nucleic acid-containing immune complexes.

• Cytokine 1 Species
• Mouse

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Alternative Names
• ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog

• Gene ID
• 2064

• UniProt ID
• P04626

• ACFP-SH047
• Anti-HER2/neu Antibody-Cytokine Fusion Protein, IgG (L19)-GM-CSF

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