Anti-HER2/neu Antibody-Cytokine Fusion Protein, IgG (rituximab)-IFNα
CAT#: ACFP-SH057
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-HER2/neu IgG to IFNα. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the HER2/neu as well as the biological activity of IFNα. Anti-HER2/neu IgG-IFNα with alpha helix linker, when contacted to a tumor cell, results in the killing or inhibition of growth or proliferation of the tumor cell. This immunocytokine was designed for treating HER-2/neu over-expressing cancer.








Specifications
- Target
- HER2/neu
- Molecule Class
- L Kappa; IgG1-IFNα
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- rituximab
- Related Disease
- HER-2/neu over-expressing cancer
- Cytokine 1
- IFNα
- Cytokines 1 Description
- Interferon alpha-1/13 is a protein that in humans is encoded by the IFNA1 gene. In humans, there are 13 different IFN-alpha genes, designated as IFN-α1,-α2,-α4,-α5,-α6,-α7,-α8,-α10,-α13,-α14,-α16,-α17 and-α21, and one each of the IFN beta (IFNB), IFN-Epsilon, IFN-Kappa and IFN-Omega genes. The human IFNA gene family shares 70-80% amino acid sequence homology, and about 35% identity with IFNB. The high degree of amino-acid sequence similarity within the IFNA genes suggests a common ancestor gene. It seems likely that the IFNA gene cluster has been generated by gene conversion or recent duplication events. There are 12 functional human IFNA gene products. All of these IFN-α proteins exhibit high homology in their primary, secondary, and tertiary structures. IFNA and IFNB are produced by a wide range of cells such as macrophages, fibroblasts and endothelial cells, but plasmacytoid dendritic cells (pDCs) are considered the main producers of IFNA in response to RNA or DNA viruses or nucleic acid-containing immune complexes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog
- Gene ID
- 2064
- UniProt ID
- P04626
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Related Diseases
Related Signaling Pathways
Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "Clone rituximab"
- CAT
- Product Name
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CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-761 | Anti-ERBB2 Recombinant Antibody (Margetuximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
TAB-049CT | Anti-Human HER2/neu Recombinant Antibody (ChA21) | IHC, Inhib, WB, Activ, FC | Chimeric antibody (mouse/human) |
TAB-049CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
TAB-049CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G022E | Anti-ERBB2 immunotoxin 4D5 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G022D | Anti-ERBB2 immunotoxin 4D5 (scFv)-DT | Cytotoxicity assay, Function study | |
AGTO-G022G | Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel | Cytotoxicity assay, Function study | |
AGTO-G022R | Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA | Cytotoxicity assay, Function study | |
AGTO-G022S | Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-126 | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (PFBL-126) | ELISA, WB, FuncS | Human Fab |
PFBZ-041 | Human Anti-ERBB2 Recombinant Antibody (clone bH1); Fab Fragment | WB, IF, FuncS | Human Fab |
HPAB-M0073-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0073-YC-F(E)) | ELISA, FC | Human Fab |
HPAB-M0074-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0074-YC-F(E)) | ELISA, FC | Human Fab |
HPAB-M0075-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0075-YC-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PNBL-066 | Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-066) | SPR | Llama VHH |
PNBL-067 | Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-067) | SPR | Llama VHH |
PNBL-069 | Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-069) | ELISA | Llama VHH |
HPAB-1026WJ | Recombinant Camelid Anti-ERBB2 Single Domain Antibody | ELISA | Camelid VHH |
HPAB-0725-YJ-VHH | Camelid Anti-ERBB2 Recombinant Single Domain Antibody (HPAB-0725-YJ-VHH) | ELISA | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-466 | Human Anti-ERBB2 Recombinant Antibody (clone mAb37) | WB | Human IgG |
FAMAB-0098YC | Mouse Anti-ERBB2 Recombinant Antibody (clone E402) | Cyt | Mouse IgG1, κ |
FAMAB-0099YC | Human Anti-ERBB2 Recombinant Antibody (clone CH402) | Cyt | Chimeric (mouse/human) IgG1 |
FAMAB-0132CQ | Mouse Anti-ERBB2 Recombinant Antibody (clone SER4) | ELISA | Mouse IgG1 |
HPAB-0091-FY | Human Anti-ERBB2 Recombinant Antibody (clone MIL12) | ELISA | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-041 | Human Anti-ERBB2 Recombinant Antibody (clone bH1); scFv Fragment | WB, IF, FuncS | Human scFv |
HPAB-1111LY-S(P) | Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1111LY-S(P)) | ELISA | Mouse scFv |
HPAB-1112LY-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1112LY-S(P)) | ELISA | Human scFv |
HPAB-1129-FY-F(E) | Human Anti-ERBB2 Recombinant Antibody (clone Her2-S1R2A-CS-1F7); scFv Fragment | ELISA, WB, FC, IF, IP | Human scFv |
HPAB-1130-FY-F(E) | Human Anti-ERBB2 Recombinant Antibody (clone Her2-S1R2A-CS-1D11); scFv Fragment | ELISA, WB, FC, IF, IP | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0191CL | Human Anti-ERBB2 Recombinant Antibody (TAB-0191CL) | ELISA, Cyt, Internalization | Human IgG |
TAB-056CT | Human Anti-ERBB2 Recombinant Antibody (TAB-056CT) | WB | Human IgG |
PABX-081 | Recombinant Human Anti-HER2 Antibody (Gr3) | WB, ELISA, FuncS | IgG |
PABX-082 | Recombinant Human Anti-HER2 Antibody (Gr6) | WB, ELISA, FuncS | IgG |
PABX-081-S (P) | Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr3) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-033CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-033CT-F(E)) | ELISA, WB | Humanized Fab |
TAB-038CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-038CT-F(E)) | WB | Humanized Fab |
TAB-039CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (h1E11) | WB | Humanized antibody |
TAB-041CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-041CT-F(E)) | ELISA, WB | Humanized Fab |
TAB-050CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (HuA21) | ELISA, WB | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-024LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-117LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
Gly-145LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
Gly-146LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
Gly-147LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
Gly-148LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-177LC | Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0195MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-737CQ | Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) | Block, IP, IF, FC | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1178 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB) | IHC-P, IHC-Fr | Rabbit IgG |
MOR-4586 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS) | WB | Rabbit IgG |
MOR-4587 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC2500 | PE-B*53:01/Human ERBB2 (LPQPPICTI) MHC Tetramer | FCM | |
MHC-LC2501 | PE-B*54:01/Human ERBB2 (LPQPPICTI) MHC Tetramer | FCM | |
MHC-LC2509 | PE-B*07:02/Human ERBB2 (LPTNASLSF) MHC Tetramer | FCM | |
MHC-YF221 | A*02:01/Human Her-2/neu (KIFGSLAFL) MHC Monomer | MHC Multimer | |
MHC-YF222 | A*02:01/Human Her-2/neu (RLLQETELV) MHC Monomer | MHC Multimer |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-468CQ | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-468CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-053 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-053) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-761 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-761) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-005 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-005) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0424-XY91 | AbPlus™ Anti-ERBB2 Magnetic Beads (3.F2) | IP, Protein Purification | |
VS-0724-YC1516 | AbPlus™ Anti-Erbb2 Magnetic Beads (VS-0724-YC1516) | IP, Protein Purification |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0125-FY24 | Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera | FC, BI | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY108 | CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2) | FC | Mouse IgG1, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC430 | Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY2335 | Anti-ERBB2 Immunohistochemistry Kit | IHC | |
VS-0525-XY2336 | Anti-Mouse ERBB2 Immunohistochemistry Kit | IHC |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-YC3 | Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab | ELISA | Symmetric scFv-Fab |
VS-0525-YC6 | Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero Fab | ELISA | Asymmetric hetero Fab |
VS-0525-YC7 | Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero HC-LC | ELISA, Inhib | Asymmetric hetero HC, common LC |
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