Afuco™ Anti-Human HLA-DR βchain ADCC Recombinant Antibody (1D09C3), ADCC Enhanced (CAT#: AFC-346CL)
Anti-HLA-DR βchain ADCC Enhanced Antibody (1D09C3) is an ADCC enhanced antibody produced by our Afuco™ platform. 1D09C3 is a human monoclonal IgG4-type antibody against human leukocyte antigen-DR (HLA-DR) which has demonstrated pro-apoptotic activity against lymphoid tumors in vitro and in vivo. 1D09C3 could be administered safely in patients with advanced B cell malignancies.
Specific Inquiry
Figure 7 The mAb 1D09C3 in a dose response experiments in a Non-Hodgkin's Lymphoma Model (Granta-519).
The mAb 1D09C3 exhibits comparable efficacy within a does range of l mg to 2.5 μg /mouse (50 mg to 125 μg/kg). Efficacy titrates between 2,5 μg (full efficacy) and 25 ng/mouse (no detectable efficacy).
Figure 8 Combination of 1 D09C3 and Rituxan in Non-Hodgkin' s Lymphoma (NHL) Model (Granta-519).
The anti-HLA-DR mAb 1D09C3 shows a clear synergism with the anti-CD20 mAb Rituxan in an NHL model. Single therapies with each antibody show comparable efficacies.
Figure 9 Efficacy in different xenotransplant models.
The 1D09C3 mAb is effective in xenotransplant models of Hodgkin' s lymphoma, non-Hodgkin' s lymphoma, multiple myeloma and hairy cell leukemia.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- B-cell malignancies
Product Property
- Purity
- >95% by HPLC
- Storage
- Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.
Target
- Alternative Names
- HLA-DR Beta chain; Human Leukocyte Antigen-DR Beta chain; DR Beta chain
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "HLA-DR βchain"
Select a product category from the dropdown menu below to view related products.
Please select product type
Human Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-361CL | Anti-Human HLA-DR βchain Recombinant Antibody (1D09C3) | FC, FuncS | Antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AFC-346CL. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
-1.png)
Application: WB, ELISA, FC, IHC, IP
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, PD, Activ, PK, Stim
Application: Neut, FuncS, IHC, ELISA, FC, Inhib
Application: WB, IHC-Fr, IHC-P, ICC, IF
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
