Products

muromonab-CD3 (TAB-019)

Recombinant monoclonal antibody to Human CD3. Muromonab-CD3 (trade name Orthoclone OKT3,) is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first monoclonal antibody to be approved for clinical use in humans.      

Specifications
Immunogen
The details of the immunogen for this antibody are not available.
Host
Mouse
Derivation
Mouse
Type
IgG2a - kappa
Specificity
Tested positive against native human antigen
Species Reactivity
Human
Applications
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
Trade name
orthoclone okt3
CAS NO.
140608-64-6
Generic Name
muromonab-CD3
ATC Code
L04AA02
DrugBank
DB00075
UNII
JGA39ICE2V
ChEMBL
CHEMBL1201608
M.W.
146.091 kDa
Related Disease
Acute kidney transplant rejection, Acute kidney transplant rejection (reversal)
Target
Alternative Names
muromonab-CD3; orthoclone okt3; 140608-64-6; Orthoclone OKT3; DB00075 CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain
Entrez Gene ID
916
UniProt ID
P07766

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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