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Anti-TNFα Recombinant Antibody (Afelimomab) (CAT#: TAB-718)

Recombinant mouse monoclonal antibody F(ab')2 fragment expressed in CHO binding to human TNFα. Afelimomab is an anti-TNFα monoclonal antibody. Administration of afelimomab reduces the concentration of interleukin-6 in patients with sepsis, but reduces mortality only marginally.


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Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 Tonsil
Figure 1 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000232810-TNF
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF

Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • F(ab')2 - G3 - kappa
  • Species Reactivity
  • Human
  • Applications
  • Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, ICC and most other immunological methods.
  • CAS
  • 156227-98-4
  • Generic Name
  • Afelimomab
  • ATC Code
  • L04AB03
  • Related Disease
  • Sepsis toxic shock

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • Store at -20°C. Avoid multiple freeze/thaw cycles.

Target

  • Alternative Names
  • Afelimomab;156227-98-4;MAK 195F;LU54107;MAK 195F;TNF;tumor necrosis factor;TNFA, tumor necrosis factor (TNF superfamily, member 2);DIF;TNF superfamily;member 2;TNF alpha;TNFSF2;TNF-a;cachectin;APC1 protein;TNF, monocyte-derived;TNF, macrophage-derived;TNF

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Afelimomab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Afelimomab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "TNF"

Mouse Antibody

CAT Product Name Application Type
TAB-768 Anti-TNF alpha Recombinant Antibody (Nerelimomab) FuncS, IF, Neut, ELISA, FC, IP, ICC IgG1
TAB-311CT Anti-Human TNFα/RANKL Recombinant Antibody (8G12) Neut, ELISA, FC
TAB-311CT-S(P) Anti-Human TNFα/RANKL Recombinant Antibody scFv Fragment (8G12) Neut, ELISA, FC
TAB-112CQ Anti-Human TNF Recombinant Antibody (A10G10) Neut, ELISA, WB
TAB-116CQ Anti-Human TNF Recombinant Antibody (Vh5/Vk12) ELISA

Humanized Antibody

CAT Product Name Application Type
TAB-034-F(E) Anti-Human TNF alpha Recombinant Antibody Fab Fragment (Certolizumab Pegol) ELISA, FC, IP, FuncS, IF, Neut, IHC Fab'
TAB-110CQ Anti-Human TNF Recombinant Antibody (CDP571) ELISA Humanized antibody
TAB-114CQ Human Anti-TNF Recombinant Antibody (TAB-114CQ) ELISA, FC, Inhib Humanized antibody
TAB-115CQ Human Anti-TNF Recombinant Antibody (TAB-115CQ) ELISA, FC, Neut Humanized antibody
TAB-118CQ Anti-Human TNF Recombinant Antibody (YHB1411-2) FC, ELISA Humanized antibody

Rat Antibody

CAT Product Name Application Type
TAB-623CL Bovine Anti-TNF Recombinant Antibody (TAB-623CL) Neut Bovine IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-148CQ Anti-Human TNF Recombinant Antibody ELISA Chimeric antibody (mouse/human)
TAB-402CQ Human Anti-TNF Recombinant Antibody (TAB-402CQ) ELISA Chimeric (mouse/human) IgG
TAB-148CQ-S(P) Anti-Human TNF Recombinant Antibody scFv Fragment ELISA Chimeric antibody (mouse/human)
TAB-402CQ-S(P) Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P)) ELISA Mouse scFv
TAB-148CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment ELISA Chimeric antibody (mouse/human)

Human Antibody

CAT Product Name Application Type
TAB-133CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (2SD4) ELISA, Neut Human antibody
TAB-135CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (AE11-5) ELISA, Neut Human antibody
TAB-136CQ-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-136CQ-F(E)) ELISA, Block Human Fab
TAB-404CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (BPC1494) ELISA, WB Human antibody
TAB-405CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment (XENP6401) ELISA Human antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-083LC Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) ELISA, FC Human antibody
Gly-085LC Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA, FC Human antibody
Gly-086LC Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) ELISA, FC Human antibody
Gly-087LC Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) ELISA, FC Human antibody
Gly-163LC Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA Chimeric antibody (mouse/human)

Non-hyper Galactosylated

CAT Product Name Application Type
Gly-083LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) ELISA, FC Human antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-085LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA, FC Human antibody
Gly-163LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA Chimeric antibody (mouse/human)

Hyper-galactosylated

CAT Product Name Application Type
Gly-086LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) ELISA, FC Human antibody
Gly-087LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) ELISA, FC Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0609MZ Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY Indirect ELISA, WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2051CQ Mouse Anti-TNF Recombinant Antibody (clone CBL589) ELISA, ICC, Neut Mouse IgG1
NEUT-2052CQ Mouse Anti-TNF Recombinant Antibody (clone CBL570) WB, Neut Mouse IgG2b
NEUT-2053CQ Mouse Anti-TNF Recombinant Antibody (clone CBL571) WB, Neut Mouse IgG1
NEUT-2054CQ Rat Anti-Tnf Recombinant Antibody (clone mAb0856) Neut Rat IgG1
NEUT-2108CQ Mouse Anti-TNF Recombinant Antibody (clone mAb11) ELISA, CyTOF, FC, ICFC, ICC, IF, IHC, Neut Mouse IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-2057CQ Rat Anti-Tnf Recombinant Antibody (clone XT3) Block, ELISA, IHC, WB Rat IgG1
NEUT-2070CQ Mouse Anti-TNF Recombinant Antibody (clone 4F4) Block, ELISA, ICC, IF, IHC, WB Mouse IgG1
NEUT-2071CQ Rabbit Anti-TNF Recombinant Antibody (clone 6E10) Block, ELISA, IHC, WB Rabbit IgG1
NEUT-2082CQ Mouse Anti-TNF Recombinant Antibody (clone B-C7) Block Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4460 Rabbit Anti-TNF Recombinant Antibody (clone SI554DS) ELISA Rabbit IgG
MOR-4461 Rabbit Anti-TNF Recombinant Antibody (clone SI555DS) Neut Rabbit IgG
MOR-4462 Rabbit Anti-TNF Recombinant Antibody (clone SI556DS) FC Rabbit IgG
MOR-4751 Rabbit Anti-Tnf Recombinant Antibody (clone TH265DS) WB Rabbit IgG
MOR-4752 Rabbit Anti-TNF Recombinant Antibody (clone TH266DS) ELISA Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0007-YC Human Anti-TNF Recombinant Antibody (clone cA2) ELISA, Neut Chimeric (mouse/human) IgG1
HPAB-0675-CN Human Anti-TNF Recombinant Antibody (HPAB-0675-CN) ELISA, Neut Humanized IgG
HPAB-0676-CN Human Anti-TNF Recombinant Antibody (HPAB-0676-CN) ELISA, Neut Humanized IgG
HPAB-0677-CN Human Anti-TNF Recombinant Antibody (HPAB-0677-CN) ELISA, Neut Humanized IgG
HPAB-0678-CN Human Anti-TNF Recombinant Antibody (HPAB-0678-CN) ELISA, Neut Humanized IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0007-YC-F(E) Human Anti-TNF Recombinant Antibody (clone cA2); Fab Fragment ELISA, Neut Human Fab
HPAB-0321CQ-F(E) Human Anti-TNF Recombinant Antibody (clone mAb A1); Fab Fragment ELISA, Neut Human Fab
HPAB-0322CQ-F(E) Rat Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0322CQ-F(E)) ELISA, FC, Inhib Rat Fab
HPAB-0323CQ-F(E) Rat Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0323CQ-F(E)) ELISA, FC, Inhib Rat Fab
HPAB-0557LY-F(E) Human Anti-TNF Recombinant Antibody (clone CBL013LY); Fab Fragment ELISA Human Fab

Single-domain Antibody

CAT Product Name Application Type
PABC-545 Recombinant Llama Anti-TNF Single Domain Antibody (VHH3) FuncS, ELISA, Neut Llama VHH
PABC-546 Recombinant Llama Anti-TNF Single Domain Antibody (VHH2) ELISA, Neut Llama VHH
PABC-547 Recombinant Llama Anti-TNF Single Domain Antibody (VHH1) FuncS, ELISA, Neut Llama VHH
HPAB-M0402-YC Recombinant Chiloscyllium shark Anti-TNF Single Domain Antibody (3D2) ELISA Chiloscyllium shark vNAR single domain antibody
HPAB-AP531-YC Camel Anti-TNF Recombinant Antibody (HPAB-AP531-YC) ELISA Camel VHH

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-768 Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-006 Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-010 Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced FC, IP, ELISA, Neut, FuncS ADCC enhanced antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0930-FY-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0930-FY-F(E)) ELISA Humanized Fab
HPAB-0931-FY-F(E) Human Anti-TNF Recombinant Antibody (clone PPS4); scFv Fragment FuncS Human scFv
HPAB-0933-FY-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0933-FY-F(E)) Neut, ELISA, RIA Humanized Fab
HPAB-0513-WJ-S(P) Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0513-WJ-S(P)) ELISA Human scFv
HPAB-1615-FY-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-1615-FY-F(E)) WB, ELISA Human Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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