Anti-Human TNF Recombinant Antibody scFv Fragment (mAb2090) (CAT#: TAB-146CQ-S(P))

The antibody binds to tumor necrosis factor α (TNFα) and blocks the ability of TNFα to bind to its receptor. It can be potentially used in the treatment of autoimmune diseases such as rheumatoid arthritis (RA).


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Anti-TNFα human MAbs 2071 and 2060 compared with Remicade®.

Figure 1 Anti-TNFα human MAbs 2071 and 2060 compared with Remicade®.

Figure 2 Anti-TNFα human MAbs 2071 and 2090 compared with Remicade® and Humira®.

Figure 2 Anti-TNFα human MAbs 2071 and 2090 compared with Remicade® and Humira®.

Figure 3 TNFα receptor blocking assay.

Figure 3 TNFα receptor blocking assay.

Results of the TNFα receptor blocking assay comparing control TNFα antibodies Remicade® and Humira® and anti-TNFα human MAbs 2071 and 2090, and control IgG.

Figure 4 HUVEC assay.

Figure 4 HUVEC assay.

Comparison of inhibition of the TNFα-induced cell surface expression of adhesion molecules with human umbilical vein endothelial cells (HUVEC) using control TNFα antibodies Remicade® and Humira® and anti-TNFα human MAbs 2071, 2090 and 271.

Figure 5 IL8 assay.

Figure 5 IL8 assay.

Measurement of TNFα-induced expression of IL-8 by human monocytes using control TNFα antibodies Remicade® and Humira® and anti-TNFα human MAbs 22071 and 2090, and control IgG.


Specifications

  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human
  • Species Reactivity
  • Human
  • Clone
  • mAb2090
  • Applications
  • ELISA, BL, FC, Neut, WB, Inhib, FuncS
  • Related Disease
  • Rheumatoid arthritis

Applications

  • Application Notes
  • The antibody was validated for ELISA, Blocking, Inhibition and Function assay. For details, refer to Published Data.

Target

  • Alternative Names
  • TNF; DIF; TNFA; TNFSF2; TNF-alpha; TNLG1F; Tumor necrosis factor

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone mAb2090"

See other products for "TNF"

Chimeric Antibody

CAT Product Name Application Type
TAB-006 Anti-Human TNF Recombinant Antibody (Infliximab) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-148CQ Anti-Human TNF Recombinant Antibody ELISA Chimeric antibody (mouse/human)
TAB-402CQ Human Anti-TNF Recombinant Antibody (TAB-402CQ) ELISA Chimeric (mouse/human) IgG
TAB-148CQ-F(E) Anti-Human TNF Recombinant Antibody Fab Fragment ELISA Chimeric antibody (mouse/human)
TAB-402CQ-F(E) Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-402CQ-F(E)) ELISA Chimeric (mouse/human) Fab

Humanized Antibody

CAT Product Name Application Type
TAB-034-F(E) Anti-Human TNF alpha Recombinant Antibody Fab Fragment (Certolizumab Pegol) ELISA, FC, IP, FuncS, IF, Neut, IHC Fab'
TAB-110CQ Anti-Human TNF Recombinant Antibody (CDP571) ELISA Humanized antibody
TAB-114CQ Human Anti-TNF Recombinant Antibody (TAB-114CQ) ELISA, FC, Inhib Humanized antibody
TAB-115CQ Human Anti-TNF Recombinant Antibody (TAB-115CQ) ELISA, FC, Neut Humanized antibody
TAB-118CQ Anti-Human TNF Recombinant Antibody (YHB1411-2) FC, ELISA Humanized antibody

Rat Antibody

CAT Product Name Application Type
TAB-623CL Bovine Anti-TNF Recombinant Antibody (TAB-623CL) Neut Bovine IgG

Single-domain Antibody

Non-hyper Galactosylated

CAT Product Name Application Type
Gly-083LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) ELISA, FC Human antibody

Sialylated IgG Glycan

CAT Product Name Application Type
Gly-085LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA, FC Human antibody
Gly-163LC-1 Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) ELISA Chimeric antibody (mouse/human)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0609MZ Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY Indirect ELISA, WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2057CQ Rat Anti-Tnf Recombinant Antibody (clone XT3) Block, ELISA, IHC, WB Rat IgG1
NEUT-2070CQ Mouse Anti-TNF Recombinant Antibody (clone 4F4) Block, ELISA, ICC, IF, IHC, WB Mouse IgG1
NEUT-2071CQ Rabbit Anti-TNF Recombinant Antibody (clone 6E10) Block, ELISA, IHC, WB Rabbit IgG1
NEUT-2082CQ Mouse Anti-TNF Recombinant Antibody (clone B-C7) Block Mouse IgG1

Recombinant Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-768 Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-006 Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-010 Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced FC, IP, ELISA, Neut, FuncS ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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