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    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    Aptide scaffold protein anti-Human HER2 (CAT#: SAP-L048)

    The aptide that bound HER2 was isolated from the library using Phage display techonology. After affinity maturation, aptide variants were identified having affinities (KD=89 nM) for HER2 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg
    Normal Tissue
    Figure 3 High expression in esophagus
    Figure 3 High expression in esophagus

    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg
    Figure 4 IHC staining of human rectum
    Figure 4 IHC staining of human rectum
    (Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg
    Figure 5 IHC staining of human urinary bladder
    Figure 5 IHC staining of human urinary bladder
    (Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg
    Figure 7 Breast
    Figure 7 Breast
    (Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg
    RNA Expression
    Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)
    Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

    Specifications

    • Scaffold Name
    • Aptide
    • Origin
    • Aptide
    • Target
    • HER2
    • Species Reactivity
    • Human
    • Expression Host
    • E. coli
    • Affinity Constant
    • 89 nM
    • Applications
    • ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

    Target

    • Alternative Names
    • aptide; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

    Related Resources

    • Related Diseases
    • Related Signaling Pathways

    Downloads

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    HPAB-1026WJ Recombinant Camelid Anti-ERBB2 Single Domain Antibody ELISA Camelid VHH

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