APC-B*07:02/Human RACGAP1 (LPQANRDTL) MHC Tetramer
CAT#: MHC-LC2105
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human RACGAP1 of peptide LPQANRDTL covering 465-473 and B*07:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39427/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43912/if_selected.jpg
Normal Tissue
Figure 3 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43912/125534_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000161800-RACGAP1
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Specifications
- Allele
- B*07:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- RACGAP1
- Antigen Species
- Human
- Peptide
- LPQANRDTL
- Range
- 465-473
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12.
- Alternative Names
- RACGAP1; Rac GTPase activating protein 1; CYK4; ID-GAP; HsCYK-4; MgcRacGAP
- Gene ID
- 29127
- UniProt ID
- Q9H0H5
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