Z-domain of protein A anti-ERBB2 (SZA-L222)

This Her2 specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=22pM) for Her2 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Scaffold Name
Z-domain of protein A
Staphylococcal protein A
Core Structure
3-α helixes
Variable Regions
13 Residues on first and second helix surface
Species Reactivity
Expression Host
E. coli
Affinity Constant
22 pM
ELISA; IHC; Microscopy; FC; WB; FuncS
Alternative Names
Staphylococcal protein A; Z-domain of protein A; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
UniProt ID

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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