Rabbit Anti-ANO1 Recombinant Antibody (clone R07-6V9)
CAT#: VS3-XY3260
This product is a rabbit recombinant antibody specific for human ANO1 (Anoctamin 1), which plays a role in transepithelial anion transport and smooth muscle contraction. It specifically recognizes and binds to ANO1. It has been used in a variety of applications, such as Immunohistochemistry-Paraffin and Flow cytometry. The recommended dilutions of Immunohistochemistry-Paraffin and Flow cytometry is 1/50-1/100.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/1715_B1_18_cr57fd049b2a359_selected.jpg
Normal Tissue
Figure 2 Seminal vesicle
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_7_6_val_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_6_6.jpg
Normal Tissue
Figure 4 Salivary gland
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_B_2_1.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_7_4.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (A-431, CAPAN-2, HaCaT, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131620-ANO1
❮
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human ANO1
- Species Reactivity
- Human
- Clone
- R07-6V9
- Applications
- IHC-P, FC
- Related Disease
- Intestinal Dysmotility Syndrome; Gastric Leiomyoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC: 1/50-1/100
FC: 1/50-1/100
Target
- Alternative Names
- DOG1; INDMS; MYMY7; TAOS2; ORAOV2; TMEM16A
- Gene ID
- 55107
- UniProt ID
- Q5XXA6
- Long Name
- Anoctamin 1
- Cellular Localization
- Cell membrane, Cell projection, Membrane
- Post Translation Modifications
- Glycosylation at Asn832 (NX_Q5XXA6 [NX_Q5XXA6-1])
Modification sites at PhosphoSitePlus (Q5XXA6)
Glycosylation from GlyGen (Q5XXA6) 1 site
- Protein Refseq
- XP_011543425.1; XP_006718665.1
- Function
- Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539).
Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca2+ store release and is also required for CFTR membrane expression.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ANO1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1781z | Mouse Anti-ANO1 Recombinant Antibody (clone 39D4) | FC, IF, IHC | Mouse IgG1, κ |
| MOB-2066CT | Mouse Anti-ANO1 Recombinant Antibody (clone EPH2.2) | IHC-Fr, IHC-P | Mouse IgG |
| VS11-QX5 | Mouse Anti-ANO1 Recombinant Antibody (clone 19F2) | IHC, WB, ELISA | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-703CT | Human Anti-ANO1 Recombinant Antibody (TAB-703CT) | ELISA | Human IgG1 |
| TAB-703CT-S(P) | Human Anti-ANO1 Recombinant Antibody; scFv Fragment (TAB-703CT-S(P)) | ELISA | Human scFv |
| TAB-704CT-S(P) | Human Anti-ANO1 Recombinant Antibody; scFv Fragment (TAB-704CT-S(P)) | ELISA | Human scFv |
| TAB-703CT-F(E) | Human Anti-ANO1 Recombinant Antibody; Fab Fragment (TAB-703CT-F(E)) | ELISA | Humanized Fab |
| TAB-704CT-F(E) | Human Anti-ANO1 Recombinant Antibody; Fab Fragment (TAB-704CT-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0177 | Hi-Affi™ Rabbit Anti-ANO1 Recombinant Antibody (clone DS177AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC339 | Recombinant Anti-ANO1 Vesicular Antibody, EV Displayed (VS-0425-YC339) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY391 | Anti-ANO1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY392 | Anti-Human ANO1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY393 | Anti-Mouse ANO1 Immunohistochemistry Kit | IHC |
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