Recombinant Anti-ANO1 Vesicular Antibody, EV Displayed (VS-0425-YC339)
CAT#: VS-0425-YC339
The Recombinant Anti-ANO1 Vesicular Antibody, EV Displayed (VS-0425-YC339) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ANO1-expressed cells or tissues. The ANO1 is a calcium-activated chloride channel that is essential for anion transport and muscle function in various tissues.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/1715_B1_18_cr57fd049b2a359_selected.jpg
Normal Tissue
Figure 2 Seminal vesicle
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_7_6_val_selected.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_6_6.jpg
Normal Tissue
Figure 4 Salivary gland
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_B_2_1.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_7_4.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (A-431, CAPAN-2, HaCaT, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131620-ANO1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ANO1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Anoctamin 1
- Biological Process
- Ion transport, Transport
- Molecular Function
- Chloride channel, Developmental protein, Ion channel
- Cellular Localization
- Plasma membrane, Nucleoplasm
- Introduction
- Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
- Alternative Names
- DOG1, FLJ10261, ORAOV2, TAOS2, TMEM16A
- Gene ID
- 55107
- UniProt ID
- Q5XXA6
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ANO1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1781z | Mouse Anti-ANO1 Recombinant Antibody (clone 39D4) | FC, IF, IHC | Mouse IgG1, κ |
| MOB-2066CT | Mouse Anti-ANO1 Recombinant Antibody (clone EPH2.2) | IHC-Fr, IHC-P | Mouse IgG |
| VS3-XY3260 | Rabbit Anti-ANO1 Recombinant Antibody (clone R07-6V9) | IHC-P, FC | Rabbit IgG |
| VS11-QX5 | Mouse Anti-ANO1 Recombinant Antibody (clone 19F2) | IHC, WB, ELISA | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-703CT | Human Anti-ANO1 Recombinant Antibody (TAB-703CT) | ELISA | Human IgG1 |
| TAB-703CT-S(P) | Human Anti-ANO1 Recombinant Antibody; scFv Fragment (TAB-703CT-S(P)) | ELISA | Human scFv |
| TAB-704CT-S(P) | Human Anti-ANO1 Recombinant Antibody; scFv Fragment (TAB-704CT-S(P)) | ELISA | Human scFv |
| TAB-703CT-F(E) | Human Anti-ANO1 Recombinant Antibody; Fab Fragment (TAB-703CT-F(E)) | ELISA | Humanized Fab |
| TAB-704CT-F(E) | Human Anti-ANO1 Recombinant Antibody; Fab Fragment (TAB-704CT-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0177 | Hi-Affi™ Rabbit Anti-ANO1 Recombinant Antibody (clone DS177AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY391 | Anti-ANO1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY392 | Anti-Human ANO1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY393 | Anti-Mouse ANO1 Immunohistochemistry Kit | IHC |
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