Recombinant Anti-ANO1 Vesicular Antibody, EV Displayed (VS-0425-YC339) (CAT#: VS-0425-YC339)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• ANO1

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Anoctamin 1

• Biological Process
• Ion transport, Transport

• Molecular Function
• Chloride channel, Developmental protein, Ion channel

• Cellular Localization
• Plasma membrane, Nucleoplasm

• Introduction
• Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

• Alternative Names
• DOG1, FLJ10261, ORAOV2, TAOS2, TMEM16A

• Gene ID
• 55107

• UniProt ID
• Q5XXA6

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