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ANO1
The TMEM16A binding molecules find uses in diagnosis and treatment of cancer, like gastrointestinal cancer, gastrointestinal stromal tumor, tumors of mesenchymal, epithelia, and all other cancers containing the 11 ql 3 amplification; as well as in diagnosis and treatment of other diseases, such as infections, inflammatory or immunological diseases.
Protein class
FDA approved drug targets, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatocytes, Late spermatids, Breast myoepithelial cells, Early spermatids, Smooth muscle cells, Suprabasal keratinocytes, Sertoli cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (A-431, CAPAN-2, HaCaT, OE19)
Interaction
Homodimer (PubMed:21056985). Interacts with CFTR (PubMed:22178883). Interacts with TRPV4 (By similarity).
Molecular function
Chloride channel, Developmental protein, Ion channel
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P
- Mouse Anti-ANO1 Recombinant Antibody (clone EPH2.2) (MOB-2066CT)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC-Fr, IHC-P
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, IF, IHC
- Anti-Human ANO1 Recombinant Antibody (TAB-041CL)
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- Species Reactivity: Human
- Type: Antibody
- Human Anti-ANO1 Recombinant Antibody (TAB-704CT) (TAB-704CT)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA
- Human Anti-ANO1 Recombinant Antibody (TAB-703CT) (TAB-703CT)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA
- Human Anti-ANO1 Antibody, mRNA (TAB-041CL-mRNA)
-
- Species Reactivity: Human
- Human Anti-ANO1 Recombinant Antibody; scFv Fragment (TAB-704CT-S(P)) (TAB-704CT-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Human Anti-ANO1 Recombinant Antibody; scFv Fragment (TAB-703CT-S(P)) (TAB-703CT-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
- Human Anti-ANO1 Recombinant Antibody; Fab Fragment (TAB-704CT-F(E)) (TAB-704CT-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
- Human Anti-ANO1 Recombinant Antibody; Fab Fragment (TAB-703CT-F(E)) (TAB-703CT-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
-
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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For Research Use Only. Not For Clinical Use.