Anti-ASTL (clone SB1) Recombinant Antibody Coupled Liposome (VS-1024-FY210)
CAT#: VS-1024-FY210
Antibody-conjugated liposomes targeting ASTL have demonstrated significant potential in ovarian cancer research. By targeting the methylated ASTL antigen, these liposomes can effectively enhance the targeting and efficacy of drugs. They not only increase drug accumulation in the tumor microenvironment but also reduce toxicity to normal cells. Overall, antibody-conjugated liposomes targeting ASTL offer new ideas and strategies for targeted therapy in ovarian cancer.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_8_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15620/36614_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000188886-ASTL
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More Infomation
Specifications
- Potential Clinical Applications
- Ovarian cancer
Product Composition
- Clone
- SB1
- Antibody Type
- IgG1, kappa
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This innovative antibody is a recombinant human monoclonal antibody that was specifically designed to bind to ASTL, a protein implicated in the regulation of cellular processes. Its design allows for high specificity and sensitivity in detecting ASTL, which is crucial for studying its role in cellular signaling and developmental biology. The unique capability of this antibody to specifically target ASTL enables scientists to explore new avenues of research, potentially leading to advancements in targeted therapies and biomarker discovery.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ASTL
- Introduction
- Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
- Alternative Names
- Astacin Like Metalloendopeptidase; Astacin-Like Metallo-Endopeptidase (M12 Family); Sperm Acrosomal SLLP1 Binding; Oocyte Astacin; Ovastacin; Astacin-Like Metalloendopeptidase (M12 Family); Astacin-Like Metalloendopeptidase
- Full Name
- Astacin Like Metalloendopeptidase
- Gene ID
- 431705
- UniProt ID
- Q6HA08
- Cellular Localization
- Cytoplasm; Cell membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus ( Q6HA08 )
Modification sites at neXtProt
- Protein Refseq
- XP_011509507.1; XP_011509509.1; XP_011509510.1; XP_054198100.1; XP_054198101.1
- Function
- Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization.
Plays a role in the polyspermy inhibition.
Probably acts as a protease for the post-fertilization cleavage of ZP2.
Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone SB1"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L044S | anti-ASTL immunotoxin D-8 (Fab)-Sap | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0630-YC | Mouse Anti-ASTL Recombinant Antibody (clone 7H2) | WB, IP | Mouse IgG1, κ |
| HPAB-3128LY | Human Anti-ASTL Recombinant Antibody (clone SB1) | ELISA, WB, IF | Human IgG2a |
| HPAB-3129LY | Human Anti-ASTL Recombinant Antibody (clone SB2) | FC, IF | Human IgG2b |
| HPAB-3130LY | Human Anti-ASTL Recombinant Antibody (clone SB4) | ELISA, WB, IF | Human IgG2a |
| HPAB-3131LY | Human Anti-ASTL Recombinant Antibody (clone SB5) | ELISA, WB, IF | Human IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0630-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 7H2); scFv Fragment | WB, IP | Mouse scFv |
| HPAB-M0631-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 6C1); scFv Fragment | WB, IP | Mouse scFv |
| HPAB-M0632-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 3F2); scFv Fragment | WB, IF | Mouse scFv |
| HPAB-M0633-YC-S(P) | Mouse Anti-ASTL Recombinant Antibody (clone 6B1); scFv Fragment | WB, IF | Mouse scFv |
| HPAB-M0634-YC-S(P) | Rabbit Anti-ASTL Recombinant Antibody (clone 1H2/1K2); scFv Fragment | WB, FC | Rabbit scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0630-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 7H2); Fab Fragment | WB, IP | Mouse Fab |
| HPAB-M0631-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 6C1); Fab Fragment | WB, IP | Mouse Fab |
| HPAB-M0632-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 3F2); Fab Fragment | WB, IF | Mouse Fab |
| HPAB-M0633-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 6B1); Fab Fragment | WB, IF | Mouse Fab |
| HPAB-M0634-YC-F(E) | Rabbit Anti-ASTL Recombinant Antibody (clone 1H2/1K2); Fab Fragment | WB, FC | Rabbit Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY21 | AbPlus™ Anti-ASTL Magnetic Beads (7H2) | IP, Protein Purification |
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