Anti-B2M (clone W24V2) Recombinant Antibody Coupled Liposome (VS-1024-FY3) (CAT#: VS-1024-FY3)

• Potential Clinical Applications
• Has potential to target tumor immunity, autoimmune diseases, etc.

• Clone
• W24V2

• Antibody Type
• IgG2a, kappa

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This antibody was produced through immunizing Balb/c mice. The immunization process involved the use of alloreactive human T cell blasts. This antibody may be used in immunological research to identify and study human-related T cell responses, as well as to evaluate MHC-associated immune responses in mouse models.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• B2M

• Introduction
• This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

• Alternative Names
• Beta-2-Microglobulin; Beta Chain Of MHC Class I Molecules; Beta-2-Microglobin; IMD43

• Full Name
• Beta-2-Microglobulin

• Gene ID
• 567

• UniProt ID
• P61769

• Sequence Similarities
• Belongs to the beta-2-microglobulin family.

• Cellular Localization
• Amyloid, MHC I, Secreted

• Post Translation Modifications
• Glycation of Ile-21 is observed in long-term hemodialysis patients.

• Protein Refseq
• NP_004039.1

• Function
• Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).

• VS-1024-FY83
• Anti-B2M (clone W24V81) Recombinant Antibody Coupled Liposome (VS-1024-FY83)

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