Anti-B2M (clone W24V2) Recombinant Antibody Coupled Liposome (VS-1024-FY3)
CAT#: VS-1024-FY3
The conjugation process involves careful optimization of conditions to ensure efficient binding between the antibody and the liposomal surface, thus preserving the functional integrity of the antibody while facilitating targeted delivery. As a result, this method opens new avenues for developing targeted drug delivery systems, enabling the focused treatment of diseases where β2-microglobulin plays a critical role, such as certain cancers and autoimmune disorders.
This advanced conjugation technique not only streamlines the process of antibody-liposome linkage but also significantly contributes to the development of novel diagnostic and therapeutic tools, paving the way for more effective intervention strategies in the treatment of various diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane, cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6361/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane, cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/if_selected.jpg
Normal Tissue
Figure 3 Spleen
High expression in spleen
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6361/18752_B_7_4_val_selected.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/6948_B_6_4.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/6948_A_8_8.jpg
Normal Tissue
Figure 6 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/6948_B_8_5.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2572/6948_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000166710-B2M
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More Infomation
Specifications
- Potential Clinical Applications
- Has potential to target tumor immunity, autoimmune diseases, etc.
Product Composition
- Clone
- W24V2
- Antibody Type
- IgG2a, kappa
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This antibody was produced through immunizing Balb/c mice. The immunization process involved the use of alloreactive human T cell blasts. This antibody may be used in immunological research to identify and study human-related T cell responses, as well as to evaluate MHC-associated immune responses in mouse models.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- B2M
- Introduction
- This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
- Alternative Names
- Beta-2-Microglobulin; Beta Chain Of MHC Class I Molecules; Beta-2-Microglobin; IMD43
- Full Name
- Beta-2-Microglobulin
- Gene ID
- 567
- UniProt ID
- P61769
- Sequence Similarities
- Belongs to the beta-2-microglobulin family.
- Cellular Localization
- Amyloid, MHC I, Secreted
- Post Translation Modifications
- Glycation of Ile-21 is observed in long-term hemodialysis patients.
- Protein Refseq
- NP_004039.1
- Function
- Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
- CAT
- Product Name
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| HPAB-0350-FY-F(E) | Mouse Anti-B2M Recombinant Antibody (clone FY-007); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1431z-S(P) | Recombinant Anti-Human B2M Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
| HPAB-0130-FY-S(P) | Human Anti-B2M Recombinant Antibody (clone B2M-1D8); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0131-FY-S(P) | Human Anti-B2M Recombinant Antibody (clone B2M-2F6); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0350-FY-S(P) | Mouse Anti-B2M Recombinant Antibody (clone FY-007); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-076 | Recombinant Anti-B2M VHH Single Domain Antibody (PNBL-076) | FACS, BL | Llama VHH |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0078MZ | Mouse Anti-B2M Recombinant Antibody (clone C2G8) | FC, IHC | Mouse IgG2a |
| MRO-1690-CN | Rabbit Anti-B2M Polyclonal Antibody (MRO-1690-CN) | WB, IHC, FC | Rabbit IgG |
| ZG-0173U | Mouse Anti-B2M Recombinant Antibody (clone 2D3E5) | ELISA, IHC | Mouse IgG1 |
| VS1-YJ11 | Mouse Anti-B2M Recombinant Antibody (clone B1) | ELISA | Mouse IgG2b |
| VS-0224-XY13 | Mouse Anti-B2M Recombinant Antibody (clone 2M2), FITC | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-1010MZ | Chicken Anti-beta-2 Microglobulin Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0312 | Hi-Affi™ Rabbit Anti-B2M Recombinant Antibody (clone DS312AB) | ELISA | Rabbit IgG |
| MOR-3971 | Hi-Affi™ Rabbit Anti-B2M Recombinant Antibody (clone SI31DS) | IHC-P | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1304 | AbPlus™ Anti-B2M Magnetic Beads (VS-0724-YC1304) | IP, Protein Purification | |
| VS-0724-YC1371 | AbPlus™ Anti-B2M Magnetic Beads (VS-0724-YC1371) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY51 | Mouse Anti-NHP B2M Recombinant Antibody (clone C21.48A1) | WB, IF, FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY218 | Anti-B2M Immunohistochemistry Kit | IHC | |
| VS-0525-XY671 | Anti-Human B2M Immunohistochemistry Kit | IHC |
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