Anti-B2M (clone W24V81) Recombinant Antibody Coupled Liposome (VS-1024-FY83) (CAT#: VS-1024-FY83)

• Potential Clinical Applications
• Glioma

• Clone
• W24V81

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• The recombinant human antibody exhibits a highly specific affinity for human beta-2 microglobulin (B2M), a small protein that plays a crucial role in the immune system. This antibody has been engineered to recognize and bind to B2M with exceptional precision, which enhances its potential applications in therapeutic and diagnostic settings.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• B2M

• Introduction
• This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Familial Visceral. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding.Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).

• Alternative Names
• Beta-2-Microglobulin; Beta Chain Of MHC Class I Molecules; Beta-2-Microglobin; IMD43

• Full Name
• Beta-2-Microglobulin

• Gene ID
• 567

• UniProt ID
• P61769

• Sequence Similarities
• Belongs to the beta-2-microglobulin family.

• Cellular Localization
• Amyloid, MHC I, Secreted

• Post Translation Modifications
• Glycation of Ile-21 is observed in long-term hemodialysis patients.

• Protein Refseq
• NP_004039.1

• Function
• Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).

• VS-1024-FY3
• Anti-B2M (clone W24V2) Recombinant Antibody Coupled Liposome (VS-1024-FY3)

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