Murine mAb m5/44 was selected based on its subnanomolar affinity for CD22 and ability to be internalized into B cells. CalichDM conjugated to m5/44 caused potent growth inhibition of CD22+ human B-cell lymphomas (BCLs) in vitro.
Host: Mouse
Isotype: Mouse IgG1
Applications: ELISA, Cyt
Figure 1 Mouse Anti-CD22 Antibody (clone m5/44) in Neut.
Competitive inhibition of the binding of murine antiCD22 mAb, m5/44, to Ramos BCL by its humanized versions assembled by combinations of four distinct grafts of heavy chain (gHa-d) and two distinct grafts of light chain (gLa, gLb). Increasing concentrations of the humanized mAb were mixed with the fixed concentration of m5/44 and then allowed to bind to Ramos BCL. Binding of the murine mAb, m5/44, was monitored by indirect immunofluorescence analysis using flow cytometry. The chimeric version of m5/44 (cL cH) was also used in this evaluation as a positive control
DiJoseph, J. F., Popplewell, A., Tickle, S., Ladyman, H., Lawson, A., Kunz, A., ... & Damle, N. K. (2005). Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22. Cancer Immunology, Immunotherapy, 54(1), 11-24.
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• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
MOB-1248z | Mouse IgG1, kappa Anti-CD22 Recombinant Antibody (MOB-1248z) | IF, FC | Mouse IgG1, κ |
MOB-0349MZ | Mouse Anti-CD22 Recombinant Antibody (clone 5LB129) | ELISA | Mouse IgG1 |
FAMAB-0047YC | Human Anti-CD22 Recombinant Antibody (clone g5/44) | ELISA, Cyt | Humanized IgG4 |
FAMAB-0048YC | Human Anti-CD22 Recombinant Antibody (clone ch5/44) | ELISA | Chimeric (mouse/human) IgG |
HPAB-0370-FY | Human Anti-CD22 Recombinant Antibody (HPAB-0370-FY) | FC, FuncS, ELISA | Humanized IgG |
CAT | Product Name | Application | Type |
TAB-198 | Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized (from mouse) IgG4, κ |
TAB-1725CL-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1725CL-S(P)) | Block, Cyt, ELISA, FuncS | Humanized scFv |
TAB-1725CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1725CL-F(E)) | Block, Cyt, ELISA, FuncS | Humanized Fab |
TAB-1729CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1729CL-F(E)) | IF, FC | Humanized Fab |
TAB-002LC-F(E) | Anti-Human CD22 Recombinant Antibody Fab Fragment (VM1000) | ELISA, SPR | Humanized antibody |
CAT | Product Name | Application | Type |
AGTO-G077E | Anti-CD22 immunotoxin RFB4 (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-G077D | Anti-CD22 immunotoxin RFB4 (IgG)-DT | Cytotoxicity assay, Function study | |
AGTO-G077G | Anti-CD22 immunotoxin RFB4 (IgG)-Gel | Cytotoxicity assay, Function study | |
AGTO-G077R | Anti-CD22 immunotoxin RFB4 (IgG)-RTA | Cytotoxicity assay, Function study | |
AGTO-L048E | anti-CD22 immunotoxin RFB4 (scFv)-PE | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
TAB-0196CL | Anti-Human CD22 Recombinant Antibody (hLL2) | Inhib, Cyt, FC, WB | |
TAB-1721CL-S(P) | Anti-Human CD22 Recombinant Antibody scFv Fragment (CD22.1) | ELISA, FC, FuncS | Human antibody |
TAB-1722CL-S(P) | Anti-Human CD22 Recombinant Antibody scFv Fragment (CD22.2) | ELISA, FC, FuncS | Human antibody |
TAB-0196CL-F(E) | Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2) | ELISA, In vivo | |
TAB-0197CL-F(E) | Anti-Human CD22 Recombinant Antibody Fab Fragment (hLL2-Cys) | ELISA, In vivo |
CAT | Product Name | Application | Type |
TAB-1714CL | Mouse Anti-CD22 Recombinant Antibody (TAB-1714CL) | ELISA, WB | Mouse IgG |
TAB-1728CL | Anti-Human CD22 Recombinant Antibody (RFB4) | IF, FC | |
TAB-003LC | Mouse Anti-Human CD22 Recombinant Antibody | FC | |
TAB-004LC | Anti-Human CD22 Recombinant Antibody | FC | |
TAB-005LC | Mouse Anti-CD22 Recombinant Antibody (TAB-005LC) | FC, Cyt, Block, Apop, ROS assay, FuncS | Mouse IgG2b |
CAT | Product Name | Application | Type |
TAB-1724CL-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-1724CL-S(P)) | Inhib | Mouse scFv |
TAB-1724CL-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-1724CL-F(E)) | Inhib | Chimeric (mouse/human) Fab |
TAB-001LC | Human Anti-CD22 Recombinant Antibody (TAB-001LC) | ELISA | Chimeric antibody (mouse/human) |
TAB-001LC-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (TAB-001LC-S(P)) | ELISA | Mouse scFv |
TAB-001LC-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (TAB-001LC-F(E)) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
Gly-001LC | Recombinant Anti-Human CD22 Antibody (Fab glycosylation) | ELISA, FC | Mouse antibody |
CAT | Product Name | Application | Type |
Gly-111LC | Recombinant Anti-Human CD22 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
NEUT-315CQ | Rat Anti-CD22 Recombinant Antibody (clone 2D6) | Block | Rat IgG1, κ |
CAT | Product Name | Application | Type |
MOR-0545 | Hi-Affi™ Rabbit Anti-CD22 Recombinant Antibody (clone DS545AB) | IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
HPAB-0194-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0194-LSX-F(E)) | ELISA | Mouse Fab |
HPAB-0195-LSX-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0195-LSX-F(E)) | ELISA | Human Fab |
HPAB-0196-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0196-LSX-F(E)) | ELISA | Mouse Fab |
HPAB-0197-LSX-F(E) | Human Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0197-LSX-F(E)) | ELISA | Human Fab |
HPAB-0198-LSX-F(E) | Mouse Anti-CD22 Recombinant Antibody; Fab Fragment (HPAB-0198-LSX-F(E)) | ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
AFC-TAB-176 | Afuco™ Anti-CD22 ADCC Recombinant Antibody (Epratuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-198 | Afuco™ Anti-CD22 ADCC Recombinant Antibody (Inotuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
HPAB-1899LY-S(P) | Mouse Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-1899LY-S(P)) | ELISA, Inhib | Mouse scFv |
HPAB-0709-FY-F(E) | Mouse Anti-CD22 Recombinant Antibody (clone AB008); scFv Fragment | ELISA | Mouse scFv |
HPAB-0370-FY-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0370-FY-S(P)) | ELISA | Humanized scFv |
HPAB-0371-FY-S(P) | Human Anti-CD22 Recombinant Antibody; scFv Fragment (HPAB-0371-FY-S(P)) | Inhib | Humanized scFv |
HPAB-2052-FY-S(P) | Human Anti-CD22 Recombinant Antibody (clone B28); scFv Fragment | FC | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.