Mouse Anti-CD22 Recombinant Antibody (clone m5/44) (CAT#: FAMAB-0046YC)

Murine mAb m5/44 was selected based on its subnanomolar affinity for CD22 and ability to be internalized into B cells. CalichDM conjugated to m5/44 caused potent growth inhibition of CD22+ human B-cell lymphomas (BCLs) in vitro.

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  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Neut

Figure 1 Mouse Anti-CD22 Antibody (clone m5/44) in Neut.

Figure 1 Mouse Anti-CD22 Antibody (clone m5/44) in Neut.

Competitive inhibition of the binding of murine antiCD22 mAb, m5/44, to Ramos BCL by its humanized versions assembled by combinations of four distinct grafts of heavy chain (gHa-d) and two distinct grafts of light chain (gLa, gLb). Increasing concentrations of the humanized mAb were mixed with the fixed concentration of m5/44 and then allowed to bind to Ramos BCL. Binding of the murine mAb, m5/44, was monitored by indirect immunofluorescence analysis using flow cytometry. The chimeric version of m5/44 (cL cH) was also used in this evaluation as a positive control

DiJoseph, J. F., Popplewell, A., Tickle, S., Ladyman, H., Lawson, A., Kunz, A., ... & Damle, N. K. (2005). Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22. Cancer Immunology, Immunotherapy, 54(1), 11-24.


Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgG1
  • Specificity
  • Human CD22
  • Species Reactivity
  • Human
  • Clone
  • m5/44
  • Applications
  • ELISA, Cyt
  • Related Disease
  • Tumor

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • SIGLEC2; SIGLEC-2

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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