Anti-ENO1 (clone W24V93) Recombinant Antibody Coupled Liposome (VS-1024-FY95) (CAT#: VS-1024-FY95)

• Potential Clinical Applications
• Glioma

• Clone
• W24V93

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a genetically engineered human monoclonal antibody that exhibits a high specificity for human enolase 1 (ENO1). As a result of recombinant DNA technology, this antibody has been designed to recognize and bind to the ENO1 protein, which plays a critical role in glycolysis and metabolic processes within human cells. ENO1 is often overexpressed in various tumors, making it a potential target for therapeutic intervention and diagnostic applications in oncology.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• ENO1

• Introduction
• This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.

• Alternative Names
• Enolase 1; 2-Phospho-D-Glycerate Hydro-Lyase; Plasminogen-Binding Protein; Phosphopyruvate Hydratase; Enolase 1, (Alpha); Non-Neural Enolase; Alpha-Enolase; EC 4.2.1.11; ENO1L1; MPB1; NNE; Epididymis Secretory Protein Li 17; C-Myc Promoter-Binding Protein-1

• Full Name
• Enolase 1

• Gene ID
• 2023

• UniProt ID
• P06733

• Sequence Similarities
• Belongs to the enolase family.

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane, Nucleus

• Post Translation Modifications
• ISGylated.

• Protein Refseq
• NP_001188412.1; NP_001419.1

• Function
• Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons.
  Stimulates immunoglobulin production.
  MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.

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