Anti-ERBB2 (clone W24V53) Recombinant Antibody Coupled Liposome (VS-1024-FY57) (CAT#: VS-1024-FY57)

• Potential Clinical Applications
• Its main potential use is in treating certain breast cancers.

• Clone
• W24V53

• Antibody Type
• IgG1, kappa

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant monoclonal antibody targeting human ErbB2 (HER2/neu), designed to interfere with the HER2 receptor. Its primary application is in the treatment of specific breast cancers.
  HER receptors are proteins located in the cell membrane that facilitate the transmission of molecular signals from the external environment, specifically from epidermal growth factors (EGFs), to the interior of the cell, regulating gene expression. These HER proteins play a crucial role in stimulating cell proliferation. In certain cancers, particularly some forms of breast cancer, there is an overexpression of HER2, leading to uncontrolled reproduction of cancer cells.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• ERBB2

• Introduction
• This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

• Alternative Names
• Erb-B2 Receptor Tyrosine Kinase 2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface Receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog; Human Epidermal Growth Factor Receptor 2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; EC 2.7.10.1; P185erbB2; MLN 19; HER2; NGL; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog)

• Full Name
• Erb-B2 Receptor Tyrosine Kinase 2

• Gene ID
• 2064

• UniProt ID
• P04626

• Cellular Localization
• Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

• VS-1024-FY214
• Anti-ERBB2 (clone 1.18.1) Recombinant Antibody Coupled Liposome (VS-1024-FY214)

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