Anti-ERBB2 (clone 1.18.1) Recombinant Antibody Coupled Liposome (VS-1024-FY214) (CAT#: VS-1024-FY214)

• Potential Clinical Applications
• Ovarian cancer, Pancreatic cancer

• Clone
• 1.18.1

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This recombinant human monoclonal antibody has been specifically designed to bind to the HER2 protein, which plays a significant role in cell growth and differentiation. Overexpression of HER2 is often implicated in various aggressive forms of breast cancer, positioning the protein as a critical target for therapeutic intervention. By effectively targeting HER2, this antibody may contribute to the development of more effective treatment options for patients suffering from HER2-positive cancers.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• ERBB2

• Introduction
• This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

• Alternative Names
• NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu

• Full Name
• Erb-B2 Receptor Tyrosine Kinase 2

• Gene ID
• 2064

• UniProt ID
• P04626

• Cellular Localization
• Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

• VS-1024-FY57
• Anti-ERBB2 (clone W24V53) Recombinant Antibody Coupled Liposome (VS-1024-FY57)

• VS-0125-FY24
• Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera

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