Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC06b) (CAT#: MRO-3452CQ)
This product is a recombinant human anti-HIV-1 monoclonal antibody. VRC06b specifically binds to gp120.
Specific Inquiry
ELISA
Figure 1 VRC06 and VRC06b displayed unique binding properties for Env gp120.
VRC06 and VRC06b preferred recognition of Env of CD4-bound conformation (stabilized core, 2CC) and of trimeric context YU2 gp140-F trimer. The CoRbs MAb 17b was used as control.
Li, Y., O'Dell, S., Wilson, R., Wu, X., Schmidt, S. D., Hogerkorp, C. M., ... & Chakrabarti, B. K. (2012). HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins. Journal of virology, 86(20), 11231-11241.
FC
Figure 2 Binding of VRC03, VRC06, and VRC06b to JR-FL gp160△CT-transfected 293T cell surface by FACS assay, represented by MFI (mean of fluorescence intensity).
R-FL gp160△CT is the cleaved trimer; JR-FL gp160△CT cleavage-defective is the uncleaved trimer, which contains two mutations that render it cleavage defective.
Li, Y., O'Dell, S., Wilson, R., Wu, X., Schmidt, S. D., Hogerkorp, C. M., ... & Chakrabarti, B. K. (2012). HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins. Journal of virology, 86(20), 11231-11241.
Neut
Figure 3 VRC06 neutralization potency against JR-FL gp160△CT virus was affected by Env mutations leading to an alteration of neutralization sensitivity.
The bar graphs depict the effects of the Env mutations △301 and T569A/I675V on the HIV sensitivity (IC50 values) to VRC06 and other CD4bs ligands.
Li, Y., O'Dell, S., Wilson, R., Wu, X., Schmidt, S. D., Hogerkorp, C. M., ... & Chakrabarti, B. K. (2012). HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins. Journal of virology, 86(20), 11231-11241.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Recognizes HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- VRC06b
- Applications
- ELISA, FC, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Neutralization, Flow Cytometry and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-380 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC06) | FC, Neut, FuncS | Human IgG |
| PABW-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 58.2) | Neut | Mouse IgG1 |
| PABC-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 83.1) | Neut | Mouse IgG1 |
| PABZ-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 0.5β) | Neut | Mouse IgG |
| PABC-062 | Recombinant Human Anti-HIV-1 gp120 Antibody (2G12) | Neut, ELISA | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 50.1); Fab Fragment | Neut | Mouse Fab |
| PFBW-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 58.2); Fab Fragment | Neut | Mouse Fab |
| PFBC-061 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 83.1); Fab Fragment | Neut | Mouse Fab |
| PSBW-160 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone F105); scFv Fragment | FC, Neut | Human scFv |
| PSBW-178 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone b12); scFv Fragment | Neut, ELISA | Human scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-517 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 44-VRC13.01); scFv Fragment | Neut | Human scFv |
| PSBL-518 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 45-46M2); scFv Fragment | ELISA, Neut | Human scFv |
| MRO-3585CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone T8); scFv Fragment | ELISA, WB | Mouse scFv |
| MRO-3586CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone V3-G2-10); scFv Fragment | Neut | Mouse scFv |
| MRO-3587CQ-S(P) | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone V3-G2-25); scFv Fragment | Neut | Mouse scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
| MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
| MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
| MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
| MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91H9) | ELISA | Single domain antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
| MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
| MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
| MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
| MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-132LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT123) | ELISA, WB, IF, Neut | Mouse antibody |
| MRO-133LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT267) | ELISA, WB, Neut | Mouse antibody |
| MRO-134LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT085) | ELISA, WB, IF, Neut | Mouse antibody |
| MRO-150LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-4) | ELISA, Inhib, FC, Neut, RIPA, DB, IP | Mouse antibody |
| MRO-152LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-136) | Neut, ELISA | Mouse antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
| MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
| MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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