Monkey Anti-HIV-1 gp41 Recombinant Antibody (clone DH570) (CAT#: MRO-4167CQ)
Recombinant Macaque Antibody to gp41. DH570 neutralized both tier 1 and tier 2 heterologous HIV strains in the TZM-bl/FcγRI assay but not in the TZM-bl assay.
Specific Inquiry
ELISA
Figure 1 Antibody accessibility of the MPER-TMD in bicelles.
Fraction of Fab not bound to the MPER-TMD at various time points.
Fu, Q., Shaik, M. M., Cai, Y., Ghantous, F., Piai, A., Peng, H., ... & Chen, B. (2018). Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proceedings of the National Academy of Sciences, 115(38), E8892-E8899.
Neut
Figure 2 DH570 mutant acquires high affinity binding and neutralization capacity in the TZM-bl neutralization assay.
BLI sensorgrams of MPER peptide-liposome binding by DH570.
Zhang, R., Verkoczy, L., Wiehe, K., Alam, S. M., Nicely, N. I., Santra, S., ... & Montefiori, D. C. (2016). Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages. Science translational medicine, 8(336), 336ra62-336ra62.
Specifications
- Host Species
- Monkey
- Type
- Monkey IgG
- Specificity
- Recognizes HIV-1 gp41
- Species Reactivity
- HIV-1
- Clone
- DH570
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp41 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP41; gp41; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone DH570"
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-486 | Recombinant Anti-HIV-1 gp41 Antibody | WB, Dot, FuncS | IgG |
| MHH-486 | Recombinant Human Anti-HIV-1 gp41 Antibody | ELISA, IP, FuncS | IgG |
| MRO-842CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1911) | WB | Mouse IgG2a |
| MRO-843CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 191) | WB | Mouse IgG2 |
| MRO-844CQ | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 10E9) | WB, RIPA, ELISA, IF | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-486-S(P) | Recombinant Human Anti-HIV-1 gp41 Antibody scFv Fragment | IF, Neut, FuncS | scFv |
| PSBS-0051 | Monkey Anti-HIV-1 gp41 Recombinant Antibody (Clone DH570.4); scFv Fragment | ELISA, Neut, FuncS | Monkey scFv |
| PSBS-0052 | Monkey Anti-HIV-1 gp41 Recombinant Antibody (Clone DH570.9); scFv Fragment | ELISA, FuncS | Monkey scFv |
| PABJ-0083-S(P) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone VRC42.04); scFv Fragment | ELISA | Human scFv |
| PABJ-0179-S(P) | Human Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PABJ-0179-S(P)) | ELISA, Neut, FuncS | Human scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-074LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (W) | ELISA | Human antibody |
| MRO-077LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (3D6) | ELISA | Human antibody |
| MRO-079LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (3D9) | ELISA | Human antibody |
| MRO-093LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (clone 43) | ELISA | Human antibody |
| MRO-025LC-F(E) | Anti-HIV-1 gp41 Recombinant Antibody Fab Fragment (4E10-IgG3) | ELISA | Human antibody |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-4045CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2-1007); Fab Fragment | ELISA | Human Fab |
| MRO-4046CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 1-167); Fab Fragment | Neut | Human Fab |
| MRO-4047CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 1-193); Fab Fragment | Neut | Human Fab |
| MRO-4048CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 126-50); Fab Fragment | ELISA | Human Fab |
| MRO-4049CQ-F(E) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 126-6 (SZ-126.6)); Fab Fragment | ELISA, RIA, WB | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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