Anti-HMMR (clone 16E10) Recombinant Antibody Coupled Liposome (VS-1024-FY62) (CAT#: VS-1024-FY62)

• Potential Clinical Applications
• Breast cancer

• Clone
• 16E10

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• The recombinant mouse antibody exhibits a high specificity and strong binding affinity towards human HMMR (hyaluronan-mediated motility receptor). This antibody has been engineered to precisely recognize and attach to the HMMR protein, which plays a significant role in various biological processes, including cell motility and tumor progression. The development of this antibody not only enhances our understanding of HMMR's function in human physiology but also opens avenues for potential therapeutic applications. By targeting HMMR, the recombinant antibody could aid in the diagnosis or treatment of diseases where HMMR is implicated, such as cancer and inflammatory conditions. Further studies are needed to explore the full potential of this antibody in research and clinical settings, particularly in its ability to modulate HMMR-related pathways and its utility in targeted drug delivery systems.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• HMMR

• Introduction
• The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

• Alternative Names
• Hyaluronan Mediated Motility Receptor; Intracellular Hyaluronic Acid-Binding Protein; Receptor For Hyaluronan-Mediated Motility; IHABP; RHAMM; Hyaluronan-Mediated Motility Receptor (RHAMM); Hyaluronan-Mediated Motility Receptor; CD168 Antigen; CD168

• Full Name
• Hyaluronan Mediated Motility Receptor

• Gene ID
• 3161

• UniProt ID
• O75330

• Cellular Localization
• Cytoplasm, cytoskeleton, Cell surface

• Post Translation Modifications
• Glycosylation at Asn133, Asn477, Asn567, and Asn588 (NX_O75330 [NX_O75330-1])
  Modification sites at PhosphoSitePlus (O75330)
  Glycosylation from GlyGen (O75330) 5 sites, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_001136028.1; NP_001136029.1

• Function
• Receptor for hyaluronic acid (HA) (By similarity).
  Involved in cell motility (By similarity).
  When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 ^oCcurs.
  May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

• HPAB-0061-YJ
• Mouse Anti-HMMR Recombinant Antibody (clone 16E10)

• HPAB-0061-YJ-S(P)
• Mouse Anti-HMMR Recombinant Antibody (clone 16E10); scFv Fragment

• HPAB-0061-YJ-F(E)
• Mouse Anti-HMMR Recombinant Antibody (clone 16E10); Fab Fragment

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