Anti-IDH1 (clone A2E8) Recombinant Antibody Coupled Liposome (VS-1024-FY106) (CAT#: VS-1024-FY106)

• Potential Clinical Applications
• Glioma

• Clone
• A2E8

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody designed to specifically target and bind to human isocitrate dehydrogenase 1 (IDH1). IDH1 is a crucial enzyme involved in cellular metabolism, and its mutations are often associated with various types of cancer.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• IDH1

• Introduction
• Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

• Alternative Names
• Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic

• Full Name
• Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic

• Gene ID
• 3417

• UniProt ID
• O75874

• Sequence Similarities
• Belongs to the isocitrate and isopropylmalate dehydrogenases family.

• Cellular Localization
• Cytoplasm, cytosol, Peroxisome

• Post Translation Modifications
• Acetylation at Lys-374 dramatically reduces catalytic activity. ( O75874-IDHC_HUMAN )
  Ubiquitination at Lys126, Lys224, Lys233, and Lys321 ( NX_O75874 [NX_O75874-1] )
  Modification sites at PhosphoSitePlus ( O75874 )
  Glycosylation from GlyGen (O75874) 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

• Protein Refseq
• NP_001269315.1; NP_001269316.1; NP_005887.2

• Function
• Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, 19935646).
  Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways.

• HPAB-0136-YC
• Mouse Anti-IDH1 Recombinant Antibody (clone A2E8)

• HPAB-0136-YC-S(P)
• Mouse Anti-IDH1 Recombinant Antibody (clone A2E8); scFv Fragment

• HPAB-0136-YC-F(E)
• Mouse Anti-IDH1 Recombinant Antibody (clone A2E8); Fab Fragment

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