Recombinant Camel Anti-KRAS (G12D) Single Domain Antibody (HPAB-AP503-YC) (CAT#: HPAB-AP503-YC)
Anti-KRAS scAbs were developed to target wild type and mutated KRAS (G12D) in order to disrupt its role in malignant cells, such as cells involved in col orectal cancer, pancreatic cancer, biliary tract cancer, lung cancer, leukemias, and other metastatic malignancies. With out being bound by a particular mechanism, it is thought that the anti-KRAS scAb binds KRAS and blocks the down stream signaling of KRAS in malignant cells. Additionally, the anti-KRAS saAb may successfully treat malignancies that are resistant to anti-EGFR biologics (e.g., cetuximab and panitumumab).
Specific Inquiry
Specifications
- Immunogen
- Recombinant human mutant KRAS (G12D)
- Host Species
- Camel
- Type
- Camel VHH
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- HPAB-AP503-YC
- Applications
- ELISA, Block, Cytotoxicity
Product Property
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles
Target
- Alternative Names
- KRAS Proto-Oncogene, GTPase; V-Ki-Ras2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog; Kirsten Rat Sarcoma Viral Oncogene Homolog; C-Ki-Ras; K-Ras 2; C-K-RAS; KI-RAS; KRAS2; RASK2; V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog; Kirsten Rat Sarcoma Viral Proto-Oncogene; Cellular Transforming Proto-Oncogene; Cellular C-Ki-Ras2 Proto-Oncogene; Transforming Protein P21; PR310 C-K-Ras Oncogene; C-Kirsten-Ras Protein
- Gene ID
- 3845
- UniProt ID
- P01116
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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