Human Anti-PCSK9 Recombinant Antibody (clone 2C7)
CAT#: VS-0323-CJ38
This human anti-PCSK9 antibody (clone 2C7) is a product that recognizes Human PCSK9.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (A-431, CACO-2, HaCaT, HeLa, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169174-PCSK9
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human PCSK9
- Species Reactivity
- Human
- Clone
- 2C7
- Applications
- Enzyme-linked Immunosorbent Assay, Western Blot, Immunoassay, Bio-layer Interferometry Analysis
- Conjugate
- Unconjugated
- Related Disease
- Cardiovascular disease; Hypercholesterolemia
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- ELISA: 5 nM-20 nM
Western blot: 5 µg/mL-10 µg/mL
Bio-layer interferometry analysis: 0.14 μg/mL-2.25 μg/mL
Target
- Alternative Names
- FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3
- Gene ID
- 255738
- UniProt ID
- Q8NBP7
- Sequence Similarities
- Belongs to the peptidase S8 family.
- Cellular Localization
- Cytoplasm; Endoplasmic reticulum; Endosome; Golgi apparatus; Lysosome; Secreted
- Post Translation Modifications
- Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation.
Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein.
Phosphorylation protects the propeptide against proteolysis.
- Protein Refseq
- NP_777596.2
- Function
- Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658).
Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827).
Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751).
Inhibits epithelial Na+ channel (ENaC)-mediated Na+ absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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Secondary Antibody
- CAT
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Recommended Dilution Buffer
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| CAT | Product Name | Application | Type |
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| TAB-0956CL | Anti-Human PCSK9 Recombinant Antibody (m7F8) | ELISA | |
| TAB-0960CL | Anti-Human PCSK9 Recombinant Antibody (Ab1) | ELISA | Rabbit mAb |
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| TAB-0960CL-S(P) | Anti-Human PCSK9 Recombinant Antibody scFv Fragment (Ab1) | ELISA | Rabbit mAb |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| HPAB-668-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-668-FY-F(E)) | Inhib | Human Fab |
| HPAB-0240-WJ-F(E) | Mouse Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-0240-WJ-F(E)) | ELISA | Mouse Fab |
| HPAB-0241-WJ-F(E) | Mouse Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-0241-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0810-CN | Human Anti-PCSK9 Recombinant Antibody (HPAB-0810-CN) | ELISA | Human IgG |
| HPAB-667-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-667-FY) | Inhib, SPR, ELISA | Human IgG2 |
| HPAB-668-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-668-FY) | Inhib, SPR | Human IgG2 |
| HPAB-1373-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-1373-FY) | ELISA | Human IgG |
| HPAB-1374-FY | Human Anti-PCSK9 Recombinant Antibody (HPAB-1374-FY) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-758 | Afuco™ Anti-PCSK9 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-758) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1374-FY-F(E) | Human Anti-PCSK9 Recombinant Antibody; Fab Fragment (HPAB-1374-FY-F(E)) | ELISA | Human Fab |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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