Rabbit Anti-PEG10 Recombinant Antibody (VS13-YC893) (CAT#: VS13-YC893)

• Immunogen
• Recombinant human PEG10.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human PEG10

• Species Reactivity
• Human

• Applications
• IHC-P

• Conjugate
• NONE

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.

• Preservative
• 0.02% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Immunohistochemistry (IHC): 1/100-1/200

• Alternative Names
• Paternally Expressed 10; Retrotransposon Gag Domain-Containing Protein 3; Retrotransposon-Derived Gag-Like Polyprotein; Mammalian Retrotransposon-Derived Protein 2; Myelin Expression Factor 3-Like Protein 1; Sushi-Ichi Retrotransposon Homolog 1; Paternally Expressed Gene 10 Protein; Mammalian Retrotransposon-Derived 2; Retrotransposon Gag Like 2; Ty3/Gypsy-Like Protein; MART2; RGAG3; Mar2;

• Gene ID
• 23089

• UniProt ID
• Q86TG7

• Long Name
• Paternally Expressed 10

• Cellular Localization
• Cytoplasm; Membrane; Nucleus

• Protein Refseq
• NP_001035242.1; NP_001165908.1; NP_001165909.1

• Function
• Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232).
  Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232).
  Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232).
  Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity).
  Involved at the immediate early stage of adipocyte differentiation (By similarity).
  Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232).
  Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509).
  May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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