Rabbit Anti-PEG10 Recombinant Antibody (VS13-YC893)
CAT#: VS13-YC893
The Rabbit Anti-PEG10 Recombinant Antibody is specific for human PEG10. PEG10, a paternally expressed gene derived from retrotransposons, encodes proteins implicated in cell proliferation and apoptosis, crucial for embryonic development with links to malignancies. The anti-PEG10 antibody can be used for Immunohistochemistry (1/100-1/200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/762_H11_1_selected.jpg
Normal Tissue
Figure 2 High expression in placenta
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21324/47975_A_2_7_selected.jpg
Normal Tissue
Figure 3 Low expression in prostate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21324/47975_A_3_5_val_selected.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/137897_A_5_6.jpg
Normal Tissue
Figure 5 Placenta
Cytotrophoblasts Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/137897_A_1_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, HAP1, Hep G2, SCLC-21H)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000242265-PEG10
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Specifications
- Immunogen
- Recombinant human PEG10.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human PEG10
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- Paternally Expressed 10; Retrotransposon Gag Domain-Containing Protein 3; Retrotransposon-Derived Gag-Like Polyprotein; Mammalian Retrotransposon-Derived Protein 2; Myelin Expression Factor 3-Like Protein 1; Sushi-Ichi Retrotransposon Homolog 1; Paternally Expressed Gene 10 Protein; Mammalian Retrotransposon-Derived 2; Retrotransposon Gag Like 2; Ty3/Gypsy-Like Protein; MART2; RGAG3; Mar2;
- Gene ID
- 23089
- UniProt ID
- Q86TG7
- Long Name
- Paternally Expressed 10
- Cellular Localization
- Cytoplasm; Membrane; Nucleus
- Protein Refseq
- NP_001035242.1; NP_001165908.1; NP_001165909.1
- Function
- Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232).
Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232).
Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232).
Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity).
Involved at the immediate early stage of adipocyte differentiation (By similarity).
Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232).
Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509).
May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "PEG10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2660 | Hi-Affi™ Recombinant Rabbit Anti-PEG10 Monoclonal Antibody (DS2660AB) | WB, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0366C | Mouse Anti-PEG10 Recombinant Antibody (ZG-0366C) | WB | Mouse IgG |
| ZG-0367C | Mouse Anti-PEG10 Recombinant Antibody (ZG-0367C) | WB, IHC, ELISA | Mouse IgG |
| ZG-0368C | Mouse Anti-PEG10 Recombinant Antibody (ZG-0368C) | WB, IHC, IF, ELISA | Mouse IgG |
| ZG-0369C | Mouse Anti-PEG10 Recombinant Antibody (ZG-0369C) | WB | Mouse IgG |
| VS3-XY1244 | Mouse Anti-PEG10 Recombinant Antibody (clone 4C10A7) | ELISA, WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC843 | AbPlus™ Anti-PEG10 Magnetic Beads (VS-0724-YC843) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1616 | Anti-PEG10 Immunohistochemistry Kit | IHC |
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