Magic™ Plant Cell Expression Service

The Magic™ Plant Cell Expression Service of Creative Biolabs established a superior eukaryotic service for expressing high-value biopharmaceuticals, such as therapeutic antibodies, functional enzymes, effective vaccines, and other biomolecules. Our plant-based expression systems confidently promise an efficient and cost-benefit production of target proteins surpassing mammalian and even some microbial systems.

Magic™ Plant Cell Expression Service

The Introduction and Application of Plant Cell Expression

Since the emerge of transgenic plants, numerous creative related technologies have been developed to achieve a rapid manufacture with truly large-scale and offer a safer and faster production of multiple biomolecules than other hosts. Generally, the plant-based expression system is composed of the whole plant system and plant cell culture system. The accumulative research has recognized the for former mode as a fast and inexpensive method for various vaccines. Meanwhile, it is more profitable for storage and distribution. In addition to the superior biosafety characteristic and cheaper scale-up, the whole plant system surpasses other traditional microbial and mammalian expression systems greatly.

Advantages of Magic™ Plant Cell Expression Service

  1. Produce a great amount of product with excellent quality control.
  2. Systematic library and toolbox composed of a fabulous vector system, a number of well-characterized plant cell lines originated from multiple plant species, and optimized culture medium.
  3. Optimal cultivation and induction with the whole range of scales from 5 L to 1000 L per batch.
  4. One-stop service: from initial design and optimization all the way down to purification and further modification with well recorded data and organized report.

The Magic™ Plant Cell Expression Service of Creative Biolabs is dedicated to offering the superior whole plant expression service for basic research and pharmaceutical applications. As for the plant cell culture system, it possesses the merits of the whole-plant system with beneficial characteristics of traditional cultures. Well-established fermentation protocols have been adopted in the production of valuable therapeutic secondary metabolites, such as shikonin and paclitaxel. Our Magic™ Plant Cell Expression Service possesses a great library composed of a number of well-characterized plant cell lines derived from the Arabidopsis thaliana, Taxus cuspidate, Catharanthus roseus, tobacco, rice, tomato, soybean, etc., such as the tobacco cultivars Bright Yellow 2 and Nicotiana tabacum 1 (NT-1). Furtherly, we take multiple advantages of the original system and optimizes every single parameter and procedure to acquire the best product carrying out actual eukaryotic post-translational modifications. We have successfully expressed multiple enzymes, interleukins, growth factors, cytokines, antigens, and hormones, and multiple complex targets such as multimeric immunoglobulins (such as scFv antibody fragment and mouse monoclonal heavy-chain) and glycoproteins maintaining correct folding, modifications, and proper bioactivities.

Magic™ Plant Cell Expression Service

The Magic™ Plant Cell Expression Service is dedicated to manifesting the great potential of the plant-based expression system for superior production of biopharmaceuticals. Our service is the most professional lab to design the best construct resulting superior yield via a series of promoters, such as the cauliflower mosaic virus (CaMV) 35S promoter, hybrid (OCS)3mas promoter, ubiquitin promoters originated from maize, rice amylase RAmy3D promoter, etc. In addition to the excellent library of leader peptides and multiple optimized transformation technologies (such as Agrobacterium tumefaciens method and particle bombardment), our service guarantees superior yield through our specific expression strategy composed of an optimized medium, process engineering, and downstream purification. If you have any question, please contact us now for more information.

Reference

  1. Hellwig, Stephan, et al. "Plant cell cultures for the production of recombinant proteins." Nature Biotechnology 22.11 (2004): 1415-1422.

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