Bispecific Antibody Conjugates (BsAb Conjugates)

Based on the most advanced techniques and years of experience in antibody engineering field, Creative Biolabs now provides custom construction and production services of various bispecific antibodies (BsAbs) formats and their immunotherapeutics derivatives including bispecific antibody conjugates. These diverse services can greatly facilitate your scientific and clinical research about bispecific antibody.

Bispecific antibodies have been proven to be effective as therapeutic agents due to their ability to target two different antigens simultaneously. According to the differences in structure, BsAbs can be classified into five groups, among which bispecific antibody conjugates are formed by utilizing chemical conjugation of antibody or antibody fragment. Based on different starting materials and various conjugation strategies, bispecific fragments, full-length antibodies or combinations can be generated. Our BsAb conjugates mainly include the following three classes:

  1. IgG-IgG
  2. Cov-X-Body
  3. ScFv1-PEG-scFv2

Figure: Alternative formats for BsAb conjugates (Mol Immunol, 2015)

Our advanced techniques, dedicated facilities and experienced scientists enable us to design and perform bispecific antibody generation meeting every client`s requirements.

We can generate different classes of bispecific antibodies, which include:

  1. Bispecific IgGs
  2. Appended IgGs 
  3. Bispecific antibody fragments
  4. Bispecific fusion proteins
  5. Bispecific antibody conjugates

Christoph Spiess, et al. Alternative molecular formats and therapeutic applications for bispecific antibodies. Mol Immunol. 2015

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