With years of experience in bispecific antibody (BsAb) engineering and production, Creative Biolabs can provide BsAbs developed for osteology study, which is a new research domain of BsAb application.
There is a rigorous balance between bone resorption and bone formation, which is maintained via the interactions between some receptors and their ligands, such as RANK/RANKL. Thus these interactions play critical regulation roles in the life process of osteoclasts. Dysregulation of the balance can cause diseases. So osteoclasts can be used as target cells for treating bone diseases. In this context, single domain antibody ALX-0141 has been developed to treat postmenopausal bone loss in phase I clinical trials. And we also design BsAbs targeting certain molecules that mediate osteoclasts survival, differentiation and activity. Administrating of these therapeutic BsAbs can partially or even completely restore the balance between bone resorption and bone formation.
According to your requirements,Creative Biolabs can assist you to select suitable antigens and formulate appropriate strategies to develop BsAbs for both scientific and clinical research purposes.