FITC-DRB1*15:01/Human PE family protein (MHVSFVMAYPEMLAA) MHC Tetramer (CAT#: MHC-YF1333)
This product is a MHC tetramer of biotinylated peptide/MHC complex composed PE family protein-derived peptide of MHVSFVMAYPEMLAA sequence and DRB1*15:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- DRB1*15:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- PE family protein
- Antigen Species
- Mycobacterium tuberculosis
- Peptide
- MHVSFVMAYPEMLAA
- Conjugate
- FITC
- Application
- FCM
Target
- Antigen Introduction
- Induces TNF-alpha release through human Toll-like receptor 2 (TLR2) signaling pathway, leading to macrophage apoptosis (PubMed:17095513, PubMed:17223373, PubMed:24106104). The signaling pathway involves TLR2-dependent activation of the mitogen-activated protein kinase kinase kinase 5 (ASK1), which activates the p38 and JNK MAPKs, leading to enhanced expression of TNF-alpha and tumor necrosis factor receptor superfamily member 1A (TNFRI) genes. Signals are amplified through classical caspase 8-dependent mitochondrial release of cytochrome c, leading to the activation of caspases 9 and 3 . Mediates Ca2+-dependent up-regulation of the anti-inflammatory cytokine IL-10. Mediates entry into macrophages in a TLR2-dependent mechanism and activates the TLR2-dependent pro-adhesive pathway.
- Alternative Names
- PE-PGRS family protein PE_PGRS33; PE_PGRS33; PE
- Gene ID
- 885551
- UniProt ID
- P9WIF5
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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