FITC-DRB1*15:01/Human PE family protein (MHVSFVMAYPEMLAA) MHC Tetramer
CAT#: MHC-YF1333
This product is a MHC tetramer of biotinylated peptide/MHC complex composed PE family protein-derived peptide of MHVSFVMAYPEMLAA sequence and DRB1*15:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- DRB1*15:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- PE family protein
- Antigen Species
- Mycobacterium tuberculosis
- Peptide
- MHVSFVMAYPEMLAA
- Conjugate
- FITC
- Application
- FCM
Target
- Antigen Introduction
- Induces TNF-alpha release through human Toll-like receptor 2 (TLR2) signaling pathway, leading to macrophage apoptosis (PubMed:17095513, PubMed:17223373, PubMed:24106104). The signaling pathway involves TLR2-dependent activation of the mitogen-activated protein kinase kinase kinase 5 (ASK1), which activates the p38 and JNK MAPKs, leading to enhanced expression of TNF-alpha and tumor necrosis factor receptor superfamily member 1A (TNFRI) genes. Signals are amplified through classical caspase 8-dependent mitochondrial release of cytochrome c, leading to the activation of caspases 9 and 3 . Mediates Ca2+-dependent up-regulation of the anti-inflammatory cytokine IL-10. Mediates entry into macrophages in a TLR2-dependent mechanism and activates the TLR2-dependent pro-adhesive pathway.
- Alternative Names
- PE-PGRS family protein PE_PGRS33; PE_PGRS33; PE
- Gene ID
- 885551
- UniProt ID
- P9WIF5
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