FITC-H-2 IAb/Mouse Ovalbumin (AAHAEINEA) MHC Tetramer
CAT#: MHC-YF1261
This product is a MHC tetramer of biotinylated peptide/MHC complex composed Ovalbumin-derived peptide of AAHAEINEA sequence covering 329-337 and H-2 IAb molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2 IAb
- Class
- Class II
- MHC Species
- Mouse
- Antigen
- Ovalbumin
- Antigen Species
- Chicken
- Peptide
- AAHAEINEA
- Range
- 329-337
- Conjugate
- FITC
- Application
- FCM
Target
- Antigen Introduction
- Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up approximately 55% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of ovalbumin is unknown, although it is presumed to be a storage protein.
- Alternative Names
- OVA; Ovalbumin
- Gene ID
- 396058
- UniProt ID
- P01012
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Efficient T Cell Tracking
Our lab highly values this tetramer for its precision in tracking antigen-specific T cells. The FITC conjugation allows easy visualization, making it an essential tool in our immunological studies. We've successfully used it to analyze T cell populations in cancer research.
Reliable and Consistent Results
Over several studies, this tetramer has consistently produced clear and reproducible results, aiding in the robust analysis of T cell responses. Its reliability boosts our confidence in exploring the complexities of immune pathways involved in autoimmunity.
Q&As
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What makes FITC conjugation beneficial in this MHC tetramer?
A: The FITC (fluorescein isothiocyanate) conjugation allows for fluorescent labeling, which facilitates the detection and quantification of antigen-specific T cells in flow cytometry applications, offering a visual means to study immune responses.
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What is the significance of using ovalbumin as the antigen in this tetramer?
A: Ovalbumin is a model antigen used frequently in immunology due to its well-characterized structure and responses. It facilitates the study of specific immune mechanisms and the testing of immunotherapeutics in preclinical models.
View the frequently asked questions answered by Creative Biolabs Support.
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