Recombinant Anti-KCNH1 Vesicular Antibody, EV Displayed (VS-0425-YC510)
CAT#: VS-0425-YC510
The Recombinant Anti-KCNH1 Vesicular Antibody, EV Displayed (VS-0425-YC510) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to KCNH1-expressed cells or tissues. KCNH1 is a complex potassium channel influencing neurotransmission, heart rate, and more. KCNH1 is linked to cancer cell growth advantages.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14551/1585_A3_4_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19445/153533_B_9_5_val_selected.jpg
Normal Tissue
Figure 3 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19445/153533_A_9_4_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76421/168968_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Enterocytes - Peripheral nerve/ganglion Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76421/168968_A_8_3.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (LHCN-M2, RH-30, RPTEC TERT1, SH-SY5Y, SK-MEL-30, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143473-KCNH1
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- KCNH1
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Potassium voltage-gated channel subfamily H member 1
- Biological Process
- Ion transport, Potassium transport, Transport
- Molecular Function
- Calmodulin-binding, Ion channel, Potassium channel, Voltage-gated channel
- Cellular Localization
- Vesicles
- Introduction
- Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
- Alternative Names
- eag, eag1, h-eag, hEAG, Kv10.1
- Gene ID
- 3756
- UniProt ID
- O95259
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Datasheet
MSDS
COA
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See other products for "KCNH1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1914 | Hi-Affi™ Recombinant Rabbit Anti-KCNH1 Monoclonal Antibody (DS1914AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1773-FY | Mouse Anti-KCNH1 Recombinant Antibody (clone ImAB5) | Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1773-FY-F(E) | Mouse Anti-KCNH1 Recombinant Antibody (clone ImAB5); scFv Fragment | Inhib, IF, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1773-FY-S(P) | Mouse Anti-KCNH1 Recombinant Antibody (clone ImAB5); Fab Fragment | Inhib, IF, IHC | Mouse Fab |
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