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ALK

Anti-ALK Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


At Creative Biolabs, our advanced platforms enable us to deliver comprehensive antibody solutions that meet our clients' specific needs, thereby supporting your meaningful research and discovery efforts globally. We strive to empower our clients to achieve their scientific goals quickly and precisely by prioritizing exceptional value and providing unparalleled technical support. Trust Creative Biolabs to be your partner in making ground-breaking research discoveries.

ALK: A Prominent Target in Cancer Therapy

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor superfamily. The activation of this gene is crucial in the pathogenesis of various human malignancies, including anaplastic large-cell lymphoma, neuroblastoma, inflammatory myofibroblastic tumors, and lung cancer. Given its limited expression in adult tissues, targeting ALK in cancer treatment is promising, with the expectation of minimal toxic effects. This makes ALK an attractive therapeutic target for developing novel cancer treatments.

Alternative Names

Anaplastic lymphoma kinase; CD246; NBLST3; anaplastic lymphoma receptor tyrosine kinase; ALK receptor tyrosine kinase; ALK (gene); anaplastic lymphoma kinase (Ki-1); Ki-1; NBLST3; Tcrz ALK CD246; NBLST3 ALK receptor tyrosine kinase ALK tyrosine kinase receptor.

Background

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, a hydrophobic stretch corresponding to a single-pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene is rearranged, mutated, or amplified in a series of tumors including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer.
Protein class

Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Oligodendrocyte precursor cells, Inhibitory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (SH-SY5Y)

Interaction

Homodimer; homodimerizes following heparin- and ligand-binding (PubMed:16317043, PubMed:25605972, PubMed:34646012, PubMed:34819673). Interacts with CBL, IRS1, PIK3R1 and PLCG1 (PubMed:15226403). Interacts with FRS2 and SHC1 (PubMed:15226403, PubMed:16878150, PubMed:17274988). Interacts with PTN and MDK (PubMed:11278720, PubMed:12122009).

Molecular function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

More Types Infomation

Anti-ALK Recombinant Antibody Products

Leveraging our advanced antibody engineering platform in Shirley, we have developed a series of innovative and effective anti-ALK recombinant antibody products. Meanwhile, we provide these premium products for clients around the world to aid your challenging antibody discovery and development projects. Please click the provided link to get more details of your interested products.

Cat. No. Product Name Target Species Host Species Applications
HPAB-1826LY Mouse Anti-ALK Recombinant Antibody Human, Mouse Mouse IgG ELISA, WB, FC
HPAB-1825LY Mouse Anti-ALK Recombinant Antibody Human, Mouse Mouse IgG ELISA, WB, FC
HPAB-1824LY Mouse Anti-ALK Recombinant Antibody Human, Mouse Mouse IgG ELISA, WB, FC
HPAB-1823LY Mouse Anti-ALK Recombinant Antibody Human, Mouse Mouse IgG ELISA, WB, FC
HPAB-1822LY Mouse Anti-ALK Recombinant Antibody Human, Mouse Mouse IgG FC, WB, ELISA, Inhib, FuncS
NS-004CN Human Anti-ALK Recombinant Antibody (clone ESBA521) Human Human IgG ELISA, WB, FuncS

Creative Quality Control

We are dedicated to empowering the biopharmaceutical community by fostering innovation in research and development with top-tier product quality and outstanding support. Customer satisfaction is at the core of our operations, which is why we meticulously maintain a robust quality management system. This ensures that our products consistently meet and often surpass industry standards. By doing so, we enhance the efficiency of the drug development process and provide exceptional value to our customers.

Customer Reviews

Excellent
Ka***a
Mouse Anti-ALK Recombinant Antibody (clone 26D9) (CAT#: MOB-1446z)
I recently used the anti-ALK recombinant antibody from Creative Biolabs to estimate expression levels in cultured human systemic anaplastic large cell lymphoma (ALCL) cells, and the results were outstanding. The antibody demonstrated high specificity and affinity, which enabled precise quantification of ALK expression in my assay. I was especially impressed by the clear and consistent signal, which made data analysis both straightforward and reliable. This antibody has proven to be an invaluable tool for my research into anaplastic large-cell lymphoma and has significantly enhanced the accuracy of my experimental findings.
20/Mar/2024
Excellent
Ri***d
Mouse Anti-ALK Recombinant Antibody (HPAB-1817LY) (CAT#: HPAB-1817LY)
I was pleased with the Western Blot results obtained using the anti-ALK antibody from Creative Biolabs, which showed a strong positive staining on the sperm cell membrane. I adhered to the recommended concentration for my experiment and observed no significant background noise, demonstrating excellent specificity.
5/Feb/2024
Excellent
Mo***n (Long-time Customer Feedback)
Hi-Affi™ Rabbit Anti-ALK Recombinant Antibody (clone DS147AB) (CAT#: MOR-0147)
I frequently acquire my antibodies from Creative Biolabs, including the anti-ALK antibody. These antibodies exhibit excellent purity and sensitivity. Additionally, they offer great value for money, with rapid delivery times and top-notch after-sales support.
2/Jul/2024

Anti-ALK Recombinant Antibody Production

Our advanced serum-free mammalian cell expression platform provides an end-to-end solution from gene synthesis to the scalable production of high-quality anti-ALK recombinant antibodies. With over five years devoted to refining our processes, we offer cost-efficient and swift production, ensuring rapid delivery of various antibody quantities.

Featured Anti-ALK Recombinant Antibody Production Platforms Fig.1 Anti-ALK recombinant antibody production: Milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti-ALK recombinant antibody production.

Fig.2 Anti-ALK recombinant antibody production: Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-ALK recombinant antibody production.

Anti-ALK Recombinant Antibody Modalities

Creative Biolabs prides itself on providing a wide array of cutting-edge recombinant antibodies tailored for researchers. Our portfolio of anti-ALK antibodies is available in multiple formats, including full-length, Fab, and scFv. Backed by our profound knowledge and years of experience in antibody engineering, we are well-equipped to offer bespoke solutions that cater to your unique research requirements.

Fig.3 The production and modalities of full-length anti-ALK recombinant antibody. (Creative Biolabs Original)Fig.3 Full-Length Anti-ALK Recombinant Antibody Production and Modalities

ALK-Targeted Drug Information

Table 1. ALK-targeted drug information.

Company Highest Phase Classification Condition
Celldex Therapeutics (Originator) Preclinical Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells)
Neuroblastoma
Celldex Therapeutics (Originator) Preclinical Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells) (Second-Generation CAR)
Neuroblastoma
Universita degli Studi di Torino (Originator) Preclinical Cancer Immunotherapy
Cancer Vaccines
DNA Vaccines
Neuroblastoma
AIST (Originator) Preclinical Oligopeptides, less than 10 AA
Peptide-Drug Conjugates
Cancer
Co-D Therapeutics
University of Wisconsin-Madison (Originator)
Wisconsin Alumni Research Foundation (Originator)
Preclinical Fixed-Dose Combinations
Micelles
Microparticles
Natural Products
Rapamycins
Taxanes
Angiosarcoma
Cancer, breast
Cancer, lung (non-small cell) (NSCLC)
CovX (Originator) Preclinical Immunoconjugates Cancer, breast
Istituto Giannina Gaslini (Originator) Preclinical Nanoparticles
Small Interfering RNA (SiRNAs)
Neuroblastoma
Kuur Therapeutics
Novartis (Originator)
Preclinical Cancer Immunotherapy
Monoclonal Antibodies
Cancer
Glioblastoma
Children's Hospital of Philadelphia (Originator)
University of Pittsburgh (Originator)
Biological Testing Cancer Immunotherapy
Chimeric Antigen Receptor-Modified T Cells (CAR T Cells)
Neuroblastoma
Children's Hospital of Philadelphia (Originator)
University of Pittsburgh (Originator)
Biological Testing Bispecific Antibody Fusions
Cancer Immunotherapy
Fc Fusion Proteins
Polypeptides, from 41 AA
Single-Chain V-Domain Antibody Fragment (scFv)
Single-Domain Antibodies
Neuroblastoma

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

If you would like to learn more about our anti-ALK recombinant antibody products, please feel free to get in touch with us at your convenience.

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