Afuco™ Anti-Human ANO1 ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-039CL)
Anti-ANO1 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. The TMEM16A binding molecules find uses in diagnosis and treatment of cancer, like gastrointestinal cancer, gastrointestinal stromal tumor, tumors of mesenchymal, epithelia, and all other cancers containing the 11 ql 3 amplification; as well as in diagnosis and treatment of other diseases, such as infections, inflammatory or immunological diseases.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/1715_B1_18_cr57fd049b2a359_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/1715_B1_18_cr57fd049b2a359_selected.jpg
Figure 2 Seminal vesicle
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_7_6_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_7_6_val_selected.jpg
Figure 3 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_6_6.jpg
Figure 4 Salivary gland
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_B_2_1.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_B_2_1.jpg
Figure 5 Colon
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_9_3.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_9_3.jpg
Figure 6 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32148/77450_A_7_4.jpg
Figure 7 RNA cell line category: Group enriched (A-431, CAPAN-2, HaCaT, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131620-ANO1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131620-ANO1
Specifications
- Host Species
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by analysis by RP-HPLC
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- ANO1; anoctamin 1, calcium activated chloride channel; DOG1; TAOS2; ORAOV2; TMEM16A; anoctamin-1; Ca2+-activated Cl- channel; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains)
- Gene ID
- 55107
- UniProt ID
- Q5XXA6
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ANO1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1781z | Mouse Anti-ANO1 Recombinant Antibody (clone 39D4) | FC, IF, IHC | Mouse IgG1, κ |
| MOB-2066CT | Mouse Anti-ANO1 Recombinant Antibody (clone EPH2.2) | IHC-Fr, IHC-P | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-703CT | Human Anti-ANO1 Recombinant Antibody (TAB-703CT) | ELISA | Human IgG1 |
| TAB-704CT | Human Anti-ANO1 Recombinant Antibody (TAB-704CT) | ELISA | Human IgG1 |
| TAB-703CT-S(P) | Human Anti-ANO1 Recombinant Antibody; scFv Fragment (TAB-703CT-S(P)) | ELISA | Human scFv |
| TAB-703CT-F(E) | Human Anti-ANO1 Recombinant Antibody; Fab Fragment (TAB-703CT-F(E)) | ELISA | Humanized Fab |
| TAB-704CT-F(E) | Human Anti-ANO1 Recombinant Antibody; Fab Fragment (TAB-704CT-F(E)) | ELISA | Humanized Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0177 | Hi-Affi™ Rabbit Anti-ANO1 Recombinant Antibody (clone DS177AB) | IHC-P | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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